四肺部吸入给药系统.pptVIP

四、肺部吸入给药系统 优点：面积, 上皮细胞间隙，肺泡、血管和淋 巴管，血流速度，无首过破坏、无促 进剂系统 限制和要求：沉着部位及重现性、长期毒性 Inhalation therapy ( Historical perspective ) 1955, Metered-does inhaler ( MDI ) developed by George Maison 1956 marketed , FDA approval May ,1974, Sugarloaf conference milestone in the clinical use of aerosolized drug therapy Inhalation therapy ( Historical perspective ) 1980s-1990s, development and delivery of drug formulation additional device , ↓ oropharyngeal loss dry powder inhaler 2000 Non-CFC propellant medications other than pulmonary dis