PINK1Parkin通路在线粒体自噬氧化损伤中的作用.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2018, 40(1): 116– 123 DOI: 10.11844/cj cb.2018.01.0222 PINK1/Parkin通路在线粒体自噬氧化损伤中的作用 梁丹阳 戴汉川* (华中农业大学动物医学院, 动物生物化学教研室, 武汉430070) 摘要 线粒体是细胞进行氧化还原反应的主要场所, 其数量、质量和功能的完整性对调节 细胞内环境稳态和维持细胞正常生理功能发挥着重要作用。当机体受不利环境影响时, 体内产生 活性氧类(reactive oxygen species, ROS)和活性氮类(reactive nitrogen species, RNS)的水平显著增 加, 导致线粒体结构紊乱与功能障碍, 引发机体氧化损伤, 并且激活PINK 1(PTEN induced putative kinase 1)/Parkin信号通路诱导的线粒体自噬, 该通路同时也参与了细胞氧化损伤过程。该文从ROS 与氧化应激、PINK 1/Parkin通路与线粒体自噬及氧化损伤等方面展开, 重点概述了PINK 1/Parkin通 路调控线粒体自噬在氧化损伤中的作用, 为抗氧化产品的研发和机体氧化损伤相关疾病的防治提 供新的思路与科学依据。 关键词 ROS; 氧化应激; PINK 1/Parkin; 线粒体自噬; 氧化损伤 The Role of PINK1/Parkin Pathway Mitophagy in Oxidative Damage Liang Danyang, Dai Hanchuan* (Animal Biochemistry Teaching and Research Office of Basic Veterinary Department, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China) Abstract Mitochondria is the main place of redox reaction for cells. The quantity, quality and functional integrity of mitochondria play an crucial role in regulating cellular homeostasis and maintaining physiological functions. When body is exposed to the harmful environmental conditions, the level of free radicals such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) increase significantly, which causing serious structure disorder and function obstacle to mitochondria, then aggravating oxidative damage of body, besides activating PINK1/Parkin pathway to induce mitochondrial autophagy. Meanwhile, this pathway also participates in the process of cellular oxidative damage. In this paper, we make a comprehensive overview from the following aspects: ROS and oxidative stress, PINK1/Parkin pathway and mit