地塞米松磷酸钠温敏凝胶的制备.pdfVIP

DOC格式论文，方便您的复制修改删减 地塞米松磷酸钠温敏凝胶的制备 （作者:___________单位: ___________邮编: ___________） 【摘要】目的 设计和制备地塞米松磷酸钠（dexamethasone sodium phosphate,DSP）温度敏感原位凝胶，为其局部应用奠定基础。 方法 优选处方，考察各种附加剂对胶凝温度的影响，调节基质浓度 以得到适宜的胶凝温度。采用差示扫描量热法（DSC）考察胶凝过程 的热效应。 结果 确定以泊洛沙姆 407 为基质制备DSP 温敏凝胶，得 到优化处方：质量分数分别为 14.1%的泊洛沙姆 407，0.2%的透明质 酸，10%的甘油，15%的丙二醇和 2%的 DSP。DSC 测得其胶凝温度为 26 ℃，而且胶凝过程热效应极低，焓变值为 0.032 J ·g-1 ·K-1。 结 论 制备的 DSP 温敏凝胶在室温下为流体，在体温条件下可发生相变 成为凝胶，值得进一步开发研究。 【关键词】温度敏感原位凝胶；地塞米松磷酸钠；泊洛沙姆 407 Abstract:Objective To design and prepare dexamethasone sodium phosphate (DSP) loaded thermosensitive in situ gel,and provide scientifi information for clinical application.Methods Selection of different materials and their influence on gelation temperature (GT),were DOC格式论文，方便您的复制修改删减 evaluated.Different GT could be obtained by adjusting the concentration of poloxamer 407.Heating curve of gelation process was investigated by employing differential scanning calorimetery (DSC).Results Poloxamer 407 was adopted as gel base to prepare DSP gel.The optimized formulation was composed of 14.1% poloxamer 407,0.2% hyaluronic acid,10% glycerin,15% propylene glycol and 2% DSP.GT of the formulation was 26 ℃ by DSC.And the DSC result displayed that delt Cp* was 0.032 J ·g-1 ·K-1,which indicated packing of micelles and micelle entanglements may be possible mechanisms of poloxamer solution gelation with increased temperature.Conclusion The optimized formulation is free flowing liquid below room temperature and converted to gel under the physiological condition,which has potential benefits of therapy. Key words: thermosensitive in situ gel; dexamethasone sodium phosphate; poloxamer 407 原位系统是指可注射的液体以对人体极小损伤方式给药后，可在 需要的组织、器官或体腔内发生相变立即固化或胶凝。其中，温度调 节机制的原位凝胶在实际应用中比较有利：利用人体温度与环境温度 的差异，既能注射给药，又可在生理温度下形成凝胶，并在所需的时 间内保持完整，而不需要有机