肿瘤成纤维细胞分泌的WNT2通过激活Wntβ-catenin信号通路促进食管癌的发展.docVIP

AbstractObjectives： Interaction between neoplastic and stromal cells plays an important role in tumour progression. It was recently found that WNT2 was frequently overexpressed in fibroblasts isolated from tumour tissue tumour fibroblasts (TF) compared with fibroblasts from non-tumour tissue normal fibroblasts in oesophageal squamous cell carcinoma (OSCC). 目的：研究肿瘤细胞和基质细胞之间的互相作用在肿瘤的进展过程中所起的作用。最近发现，在食管鳞状细胞癌（OSCC）患者中，与在非肿瘤组织中分离出来的正常的纤维母细胞相比，WNT2频繁过表达于肿瘤组织中分离出来的肿瘤成纤维母细胞。 This study aimed to investigate the effect of TF-secreted Wnt2 in OSCC development via the tumour-stroma interaction. 本研究的目的是研