炎症与组织再生.pptVIP

* * 白细胞的渗出过程： 白细胞游出时，先由轴流变为边流（margination），进而粘附（adhesion）在血管壁上，呈现白细胞壁立现象，白细胞伸出伪足穿过内皮细胞间隙，最后通过血管基底膜和血管外膜而游出（emigration）。白细胞穿出之后，基底膜复原，不残留任何痕迹。游出的白细胞进一步向炎区中心集聚（infiltration），并执行吞噬和降解（phagocytosis degradation）功能。 * * * * 短期的局限性炎症---完全吸收 组织再生---修复或瘢痕形成 播散 进展为慢性炎症 * 短期的局限性炎症---完全吸收 组织再生---修复或瘢痕形成 播散 进展为慢性炎症 In ARDS, edema fluid, fibrin, and PMNs accumulate in the alveolar compartment (upper right area). The inflammatory response can regress (undergo resolution) with return of the lung to its preinflammatory state (lower left area), or it may progress to extensive pulmonary fibrosis (lower right area). * * 近年来，CNS等有较高影响力对炎症与组织再生的关系及相关的分子机制多有关注 * * * * * 骨骼肌再生需要卫星细胞的激活。其中巨噬细胞以及Treg起调节作用。其中M1在募集卫星细胞以及促进其增殖上其重要作用；M2则在相关细胞因子的辅助下，促进卫星细胞的分化。Treg不仅可以抑制T细胞的功能，间接促进再生；还可以分泌双调蛋白直接参与卫星细胞的激活。 * The four populations, segregated by expression levels of CCR2, Ly6C, and MHC class II, perform different functions as indicated. Upon injury such as a MI, a biphasic monocyte response occurs to promote an initial inflammatory phase followed by a reparative phase mediated by Ly6Chi or Ly6Clo splenic monocytes, respectively. The two systems are linked by the ability of splenic Ly6Chi monocytes to replenish all four subsets in phase I. * Following MI, the innate immune response to cardiac injury involves activation and recruitment of macrophages in the heart, in which they function to clear cellular debris and secrete soluble factors. Macrophage populations promote regenerative processes, such as angiogenesis, in P1 mice, while work done previously in adult mice shows they mediate fibrosis and other aspects of scar formation. * * * 5、Effect of MSCs on DC precursors Hematopoietic stem cell DC progenitor DC precursor Immature DC Mature DC MSC ? X DC development MSCs induce the differentiation of regulatory DCs from CD11c+B220- DC precursors in the immature DC induction phase 5、Effect of MSCs on DC precursors DC precursor Immature DC Mature DC d1-d5 GM-CSF+IL-4 d6-d8 GM-CSF+TNF-a MSCs FHF