全能干细胞研究及在再生医学中的应用.pptVIP

Age-related macular degeneration(AMD) : ■ Leading case of blindness in developed countries and areas. ■ AMD affects elder population, particularly for people above 60. ■ Severe and irreversible, until blind. ■ Unknown causes, complicated mechanisms and no cure. ■ RPE and Photoreceptors disorders are primary changes. ■ Could be an important disease for break though of stem cell therapy. Lancet 2012 Lancet 2015 Findings: The hESC-derived RPE cells showed no signs of hyperproliferation, tumorigenicity, ectopic tissue formation, or apparent rejection. In 9 AMD patients and 9 Stargardt’s patients, visual acuity improved in 10 treated eyes, was stable in 7 eyes, and decreased in 1 eye over 22 months. Ocata Therapeutics Stem Cell Reports Vol. 4 860–872 May 12, 2015 4 patients: 2 AMD and 2 Stargardt macular dystrophy 3 improved 1 remained stable Surgeons in London have carried out a pioneering human embryonic stem cell operation in an ongoing trial to find a cure for blindness for many patients. The procedure was performed on a woman aged 60 at Moorfields Eye Hospital. It involved seeding a tiny patch with specialised eye cells and implanting it at the back of the retina. The London Project to Cure Blindness was established a decade ago to try to reverse vision loss in patients with age-related macular degeneration (AMD). Ten patients with the wet form of AMD will undergo the procedure. BBC News Sep 29, 2015 近日，第三军医大学西南医院阴正勤教授团队成功开展首例胚胎干细胞来源的色素上皮细胞(hESC-RPE)视网膜下移植术治疗湿性年龄相关性黄斑变性(wAMD)。首例患者罗某，术后患眼比术前能够多识别33个字母，视野遮挡消失，眼科各项检查显示移植细胞生存良好，患者视功能稳步提高！阴正勤教授团队在国家973项目和中国科学院先导计划项目支持下，与中科院动物所周琪教授团队合作，目前已顺利完成了3例wAMD 和5例Stargardt病的手术。 Masayo Takahashi MD, PhD September 15, 2014 - A 70-year-old female patient suffering from exudative age-related macular degeneration (AMD) has become the world’s first recipient of an experimental transplant of a cell sheet derived from induced pluripotent stem cell (iPSCs). The patient is part of the “Clinical study of autologous induced pl