7基因组注释 生物信息学PPT技术文档.pptxVIP

基因组测序、组装与注释;DNA sequencing;;Generations DNA-sequencing;DNA sequencing by the Sanger method;;Automated procedure for DNA sequencing;Human Genome Project (by Sanger Sequencing);二代测序（High throughput sequencing）;Solexa-based Whole Genome Sequencing;Illumina (Solexa);Illumina (Solexa);13;Next-gen sequencers;二代测序优缺点;三代测序：单分子测序;零模波导孔（zero-mode waveguides, ZMWs）和荧光标记在核苷酸焦磷酸链上（Phospholinked nucleotides）;Pacific Biosystems;Oxford Nanopore passes an ionic current through nanopores and measures the changes in current as biological molecules pass through the nanopore or near it.;优缺点;;;基因组注释(Genome annotat