天然药物化学 香豆素结构类型 香豆素结构类型.pptVIP

* 香豆素和木脂素 * 学习目标 掌握香豆素的结构类型，溶解性、碱水解、内酯环和显色反应等性质及其应用 掌握溶剂提取法及其应用 * 学习目标 熟悉香豆素的性状、荧光性及色谱鉴别； 熟悉木脂素的结构类型及色谱鉴别 * 学习目标 了解香豆素的水蒸气蒸馏提取法； 了解木脂素的理化性质及提取实例 * 第一节 香豆素 * 1 2 3 4 5 6 7 8 苯骈α-吡喃酮 * 分布 高等植物 数量 1200种 * 抗菌消炎作用 秦皮甲素 秦皮乙素 * 抗凝血作用 * 抗癌作用 蛇床子素 * Calophyllum lanigerum的提取物 抗HIV * 一、结构类型 简单香豆素 * 呋喃香豆素 * 白芷内酯（angelicin） 异补骨脂素（Isopsoralene ） 呋喃香豆素 * 白花前胡甲素 吡喃香豆素 * 岩白菜素 异香豆素 * 双香豆素 * Calanolide A was found in the extract of?Calophyllum lanigerum?var.?austrocoriaceum, which exists in the Malaysian rainforests (2).??The National Cancer Institute found Calanolide A to be remarkably effective against HIV-1, the most common strain of the AIDS virus in the Western world (3).??Today, Calanolide A is in the developmental drug phase and is a member of the HIV drug class of non-nucleoside reverse transcriptase inhibitors (4).??Calanolide A blocks transcription of the viral RNA into DNA within the host cell’s cytoplasm, therefore preventing replication of the HIV virus (5).??The synthesis of Calanolide A begins with a triphenol (6).??There are four ring-building reactions, one of which is a Friedel-Crafts acylation, followed by a reduction from a ketone to an alcohol in the fifth and final reaction of the synthesis (6).??Unlike many HIV drugs, Calanolide A produces mainly mild and temporary side effects (4).??For the most up-to-date information on the development of Calanolide A as an HIV drug, go to. * Calanolide A was found in the extract of?Calophyllum lanigerum?var.?austrocoriaceum, which exists in the Malaysian rainforests (2).??The National Cancer Institute found Calanolide A to be remarkably effective against HIV-1, the most common strain of the AIDS virus in the Western world (3).??Today, Calanolide A is in the developmental drug phase and is a member of the HIV drug class of non-nucleoside reverse transcriptase inhibitors (4).??Calanolide A blocks transcription of the viral RNA into DNA within the host cell’s cytoplasm, therefore preventing replication of the HIV v