肿瘤学课件 猫淋巴瘤.pptVIP

Feline lymphoma 猫淋巴癌 Characteristics 特征 55% high grade lymphomas 55％为高度发展淋巴瘤 High percentage T cell (80%?) T细胞高百分比（80％） 1/3 of all feline tumors 1/3猫有肿瘤 200 cases/100,000 population (?) 100000只猫中有200个病例？ Risk Factors 风险 FeLV infection 猫白血病感染 Younger cats often FeLV positive 青年猫通常为FeLV阳性 Increases risk of lymphoma by 62 x 增加淋巴瘤感染风险62倍 FIV infection 猫免疫缺陷症感染 Increases risk of lymphoma by 6x 增加淋巴瘤感染风险6倍 FeLV and FIV infection 猫白血病和免疫缺陷症感染 Increases risk of lymphoma by 77x 增加淋巴瘤感染风险77倍 Risk Factors 风险 The underlying cause in non-retroviral induced feline lymphomas is poorly understood 潜在因素可能是非反转录病毒的诱导猫淋巴瘤的潜在因素不明确 Possible link- 可能相关 Chronic cigarette smoke 慢性吸烟 Chronic inflammation 慢性炎症 chronic IBD 慢性炎症性肠炎 Vaccine associated FSAs- higher risk 联合疫苗－高危 Genetic – 基因 Siamese cats appear to have a predilection, mainly the mediastinal type 仙罗猫偏好出现，主要为纵隔型 WHO Staging System WHO分段系统 I: single node or extranodal site I级：单一淋巴结或其他位置 II: regional nodes, resectable GI II级：整个淋巴结，胃肠到可切除 III: non-resectable abdominal or epidural tumor, generalized nodal involvement III级：不可切除的腹部部分或硬膜肿瘤，一般淋巴结受累 IV: spleen or liver involvement IV级：脾或肝受累 V: bone marrow involvement V级：骨髓受累 Subsets a and b a和b所包含的 Classification 分类 Anatomic 解剖学 Cytologic 细胞学 Histologic 组织学 Immunotypic 免疫学 Feline Lymphoma 猫淋巴瘤 Mediastinal Lymphoma纵隔淋巴瘤 Seen in young, FeLV positive cats 青年猫，FeLV阳性 Signs = dyspnea, Horner’s syndrome 症状：呼吸困难，霍纳氏综合症 DDX鉴别诊断 heart failure 心衰 , FIP 猫传染性腹膜炎, thymoma 胸腺瘤 , diaphragmatic hernia 横膈疝, chylo/pyo thorax 乳靡胸/脓胸 Mediastinal Lymphoma纵隔淋巴瘤 mediastinum, sternal nodes, thymus 纵隔，胸淋巴结，胸腺 Pleural effusion common 常见胸膜渗出 Mediastinal lymphoma纵隔淋巴瘤 Alimentary Lymphoma消化道淋巴瘤 Seems to be a tendency for male cats to be predisposed 看似公猫易患 Most cats are DSH 大多为家庭短毛猫 Usually FeLV negative 通常FeLV阳性 Signs= anorexia, diarrhea, weight loss, vomiting 症状：厌食，腹泻，体重减轻，呕吐