各论II 27、抗甲状腺药.pptxVIP

Thyroid hormones and antithyroid drugs;Metabolism of thyroid hormones ;;1. Normalizing growth and development 2. Promoting body metabolism Body temperature; energy levels, ect. 3. Enhancing sympathetic activity 4. Cardiac effect;1. Treatment of hypothyroidism; Etiology; SECONDARY HYPOTHYROIDISM 5% of cases. Pituitary or hypothalamic neoplasm. Congenital hypopituitarism. Pituitary necrosis (Sheehan’s syndrome) ;Common signs and symptoms Cretinism: a situation induced by a insufficiency of thyroid hormone at birth and during minority, execute growth, twined facial features, increased tongue and mental detainment Adult: Fatigue, weakness, weight gain, cold intolerance Coarse, dry hair, dry and rough pale skin, hair loss Muscle cramps and frequent muscle aches Constipation(便秘) Depression Memory loss Abnormal menstrual cycles, decreased libido ;Myxedema describes a specific form of cutaneous and dermal edema secondary to increased deposition of connective tissues, as seen in various forms of hypothyroidism ;Thyroid Hormone Replacement;2. Simple goiter (单纯性甲状腺肿) Supply iodide--iodide deficiency Thyroid hormones Surgery—nodule 3. Treat after thyroid cancer surgery to reduce TSH level to inhibit recurrence of cancer ;迟钝;Antithyroid drugs;Hyperthyroidism ;Signs and Symptoms ;Symptoms of the patient with hyperthyroidism;Thyroid crisis;Thyroid crisis clinical features;Therapy for Hyperthyroidism antithyroid drugs: thiourea derivatives iodine and iodides ? receptor antagonists radioiodines: 131I surgery subtotal thyroidectomy ;Thiourea derivatives Thiouracil ---- methylthiouracil (MTU，甲硫氧嘧啶) propylthiouracil (PTU，丙硫氧嘧啶) Imidazoles ---- thiamazole (TAPAZOLE，甲巯咪唑，他巴唑) carbimazole (卡比马唑) ;Thiourea derivatives 1. Pharmacological effects (1) Inhibiting the formation of thyroid