阿托伐他汀对慢性硬膜下血肿患者钻孔术后的影响.docxVIP

阿托伐他汀对慢性硬膜下血肿患者钻孔术后的影响 陈平 王兵 廖泉 梁日初 [摘要] 目的 探讨阿托伐他汀对慢性硬膜下血肿患者钻孔术后临床疗效的影响。 方法 选择20XX年1月～20XX年5月于我院治疗的慢性硬膜下血肿患者63例，按治疗方式不同分为单纯手术组（行钻孔引流治疗，n=30）和联合治疗组（钻孔引流术后服用阿托伐他汀，n=33），对比分析两组患者的术后复发、并发症及术后1个月mRS评分等。结果 联合治疗组术后有1例復发，单纯手术组有7例复发，联合治疗组术后血肿复发的风险低于单纯手术组（P=0.0420.05）;两组术后1个月mRS评分及并发症的发生率无显著差异（P0.05）。 结论 慢性硬膜下血肿患者钻孔术后使用阿托伐他汀可明显降低术后血肿复发率，且不增加患者术后并发症。 [关键词] 慢性硬膜下血肿;阿托伐他汀;钻孔引流;复发 [中图分类号] R651.15 [文献标识码] A [文章编号] 1673-9701（2020）09-0004-03 [Abstract] Objective To investigate the effects of atorvastatin on the clinical efficacy of patients with chronic subdural hematoma after drilling. Methods 63 patients with chronic subdural hematoma who were treated in our hospital from January 20XX to May 20XX were selected， and divided into two groups according to different therapeutic regimens， namely the group treated by drilling and drainage alone（n=30） and the combination therapy group given atorvastatin after drilling and drainage（n=33）. The postoperative recurrence， complications and 1 month postoperative mRS score were compared and analyzed between the two groups. Results There was 1 case of postoperative recurrence in the combination therapy group and 7 cases of postoperative recurrence in the group treated by drilling alone. The risk of postoperative hematoma recurrence in the combination therapy group was lower than that in the group treated by drilling alone （P=0.0420.05）. There were no significant differences in 1 month postoperative mRS score， mortality， and incidence of complications between the two groups（P0.05）. Conclusion The use of atorvastatin after drilling for patients with chronic subdural hematoma can significantly reduce the recurrence rate of postoperative hematoma， without increasing postoperative complications. [Key words] Chronic subdural hematoma; Atorvastatin; Drilling and drainage; Recurrence 慢性硬膜下血肿（Chronic subdural hematoma，CSDH）是神经外科的常见病、多发病，不同研究报道其一般人群发病率为1/（10万～14.1）万，患病人群以老年人居多，随着人口老龄化的加重，可以预见CSDH的患病率将进一步增高[1-3]。目