生理学教学课件：24-nervous system-2.pptVIP

* * * * * * * 胞浆受体：性激素受体，肾上腺皮质激素受体 核受体：甲状腺激素受体 如酪氨酸激酶偶联受体，包括胰岛素受体，表皮生长因子 血小板生长因子等一些生长因子类的。丝氨酸偶联受体等等 * * * * * * * * * * * * Na+ inflow k+ outflow Nicotin-like Action The Life Cycle of Ach Henry Hallett Dale Otto Loewi for their discoveries of Ach as neurotransmitter” 1936 Nobel Prize in Medicine Dopamine Norepinerphrine Epinephrine Catecholamines Synthesis CNS CNS PNS CNS Dopamine (DA) Receptor: D1~D5 All are G Protein-Coupled Receptor Mainly involved in Somatic movement， emotion，cardiovascular activity，et al Epinephrine Mainly involved in cardiovascular activity Norepinephrine (NE) Found both in PNS CNS PNS: ---Postganglionic neurons of sympathetic nerve CNS: ---Regulation of General Behavior, e.g. Cardiovascular Activity, Body Temperature All receptors are G Protein-Coupled Receptor Constriction of Vessel uterus Relaxation of small intestine Relaxation of Vessel uterus, small intestine, bronchial Exciting Cardiac activity Excitatory Amino Acid Glutamate / Glutamic Acid (Glu) Glutamate Synthesis Amino Acid Neurotransmitter Glutamate Receptor Ion Channel-linked Receptor G-protein Linked Receptor EAATs： Excitatory Amino Acid Transporters VGLUTs： Vesicular Glutamate Transporters xCT： Glutamate-Cystine exchanger Glutamate Transporters NMDA Receptor Ca2+/Na+ Mg++ is voltage-dependant blocker Quantity location at the postsynaptic membrane is relative stable Induce Slow Prolonged postsynaptic membrane depolarization reaction Ca2+ is the main inflow ion Characters of NMDA Receptor AMPA Receptor Na+/Ca2+ Na+ is the mail inflow ion Induce Fast Postsynaptic Membrane Depolarization Reaction Have the property of desensitization quickly Quantity location at the postsynaptic membrane is unfixed Characters of AMPA Receptor Wandering Receptor ——AMPA receptor AMPA receptors can move between an intracellular pool and the neuronal surface by the processes of exo