药物投递系统.pptx

Drug Delivery System藥物投遞系統 ;;藥物釋控系統;藥物釋控系統;藥物釋控系統;【藥物釋控】：Drug Controlled Release System 將藥物以特殊的化學包覆，讓藥物在某一種狀態(如PH值改變)下適時(ex:延長)適量釋出。 這種控釋劑型的技術發展，目前廣泛地應用於一般的製藥化學工業中。;藥物釋控系統;Potential Advantages of Controlled Release Systems maintenance of drugs at therapeutically desirable levels 2. the ability to localize drugs to target organs to minimize systemic effects 3. improved patient compliance 4. protection from degradation for drugs with short in vivo lifetimes.;Controlled Release vs. Single Dose;藥物釋控系統;Types of Controlled Release Devices;;2.Chemically controlled ˙ erosion： Surface erosion, Bulk erosion; 2.Chemically controlled ˙ pendent chain;3. Solvent-activated controlled;Biodegradable Polymers;;Application;Targeting moiety for cell;Introduction;EPR effect;Introduction;Schematic presentation of ligand-containing, shielded DNA complexes for tumor-targeted gene transfer;Targeting Moiety;Targeting Moiety;Targeting Moiety;Toxin Moiety;Toxin Moiety;Linkers;Factors affecting the potency of an IT;Clinical trials;Conclusions;References;Overview of Worldwide Drug Market;Worldwide drug market sales;2003全球各區域藥品市場銷售額;全球十大藥物銷售;Drug delivery system market;Drug delivery system;Oral controlled release;Polymer;Pulmonary;Transdermal;Transmucosal;Major drug delivery company stock2004.5.4;ALZA;;Products;;;;Biogen Idec (BIIB);;;RITUXAN (R);;Alkermes;;The unique AIR particle is a low density, porous structure with a geometric diameter of 5 - 30 μm * * Particles with mass densities less than 0.4g/cubic centimeter and mean diameters exceeding 5 micrometers were inspired deep into the lungs and escaped the lungs’ natural clearance mechanisms until the inhaled particles delivered their therapeutic payload David A. Edwards,* Justin Hanes,….,SCIENCE.VOL.276.20.JUNE.1997 ;Ease of use;;東洋製藥核心技術;微脂體;長效舒緩劑型---釋控技術;;;The End;9、春去春又回，新桃换旧符。在那桃花盛开的地方，在这醉人芬芳的季节，愿你生活像春天一样阳光，心情像桃花一样美丽，日子像桃子一样甜蜜。12月-2012月-20Thursday, December 3, 2020 10、人的志向通常和他们的能力成正比例。00:06:5400:06:5400:0