肝脏病理_ppt文件文件.docx

S. J. YANG 2006 S. J. YANG 2006 S. J. YANG 2006 S. J. YANG 2006 Welcome 肝脏疾病病理学诊断 Outline of Guidelines Classification of liver diseases Toxic injury to the liver Drug induced Industrial and environmental toxin 4. Tumors Primary malignant tumors Metastatic malignant tumors 3. Alcoholic lenign hepatic tumors 4. Tumor-like lesion5. 4. Tumor-like lesion 5. Inherited Wilsons disease Hemochromatosis Inborn errors Alpha-1-antitrypsin deficiency Cyst 4. Postoperative hepatic dysfunction Infectious agents and parasites Hepatitis virus Bacterial and other pathogenic agents Parasites Immune disorder Autoimmune Primary biliary cirrhosis LIVER CIRRHOSIS AND CHRONIC LIVER DISEASE MORTALITY RATES,Age-Adjusted fJanmeiropoiitan Counties and Chronic Lver 録Deaths per lOQ.frOO Popjlation ifcwraiianrlrta^s ntiio r-ide的收博4 ifcwraiianrlrta^s ntiio r-ide 8^19122 ￡39? 59 to 麼(533 I io 59 CIQ05Ino LJCilltt (1491 Mdc Atfr Irtc S湖部邮 Ort 如 DEh rale is a livEgr 困efdfie fdr I99O-1D54 Scxirca: l^bonal Center tar H-alti Statistics. 39W:Ala^a Bufemi d Wai Stahrtics.】.毀L Prajixed by: fclorth Caraiina Rural Health ReMarch and ftfccy /natas C enter, Cecil G. Sheps Canter for Heattti Sent css Resaarrh. □! Ncrib Cardim al Chapd k4la *1小 aj|ipat from Hw federal Office rrf fturaJ Heaitli P^ilicj/ H題A US ClHHE. Liver BiopsyLiver .. Liver Biopsy Liver .. A small slender core of tissue is removed with a biopsy needle wT\DAJVL S.J.YANG20D6 S. J. YANG 2006 S. J. YANG 2006 S. J. YANG 2006 S. J. YANG 2006 Liver Biopsy Confirm the diagnosis Serological blood tests Establish degree of fibrosis Serology Biopsy not representative Identify cirrhosis Determine optimum therapy Liver biopsy adequacy □ “Most hepatopathologists are satisfied with a biopsy specimen containing at least six to eight portal tracts. -Bravo AA et al NEJM 344, 495; 2001. 口 We should not be primarily concerned with the size of biopsy that satisfies” the pathologist. ■ The correct question is: 一 What size of biopsy will provide a rel