围术期组织低灌注与术后并发症的相关性.pptx

围术期组织低灌注与术后并发症的相关性目录围术期炎症反应与组织低灌注1低灌注是休克的始动环节2治疗原则3围术期炎症反应诱发因素术前焦虑等情绪变化手术创伤围术期炎症反应术后疼痛麻醉其他，如缺血、感染等输血谭基明主编. 外科病理生理学.第2版, 人民卫生出版社炎症产生低灌注，而低灌注引起炎症细胞因子、趋化因子、中性粒细胞，和巨噬细胞导致机体处于促炎状态，引起局部和全身炎症反应这种炎症反应使血管渗透性增高，从而导致低灌注和第三间隙水肿更深刻而言，正如Greer 和Burchard所表述的：“炎症产生低灌注，而低灌注引起炎症”，导致自身恶性循环，从而引起大血管和微血管的功能障碍It is believed that the release of cytokines, chemokines, neutrophils, and macrophages lead to a pro-inflammatory state causing local and systemic inflammation.Such inflammation increases vascular permeability that can lead to hypoperfusion and third spacing of fluids.Often this is profound, as described by Gree