贝尼地平治疗原发性高血压的疗效观察.docVIP

贝尼地平治疗原发性高血压的疗效观察 【摘要】 目的用动态血压监测(ABPM)的方法评价 贝尼地平治疗原发性高血压的疗效。方法选择原发性高血压患者56 例，随机分为贝尼地平组26例，厄贝沙坦组30例。分别观察服药前 和服药后(8周末)的血压变化及贝尼地平服药前、后的24h，白昼、 夜间的动态血压变化。结果 贝尼地平组服药8周后SBP和DBP下降 (16.9±11.8 )和(12. 8 ±9. 2) mmHg ( Plt; 0. 01 )。厄贝沙坦组 SBP 和 DBP 下降(14. 8 ±10. 9 )和(11.2土 7) mmHg (Plt; 0. 01 )e 动态 血压资料分析示服用贝尼地平后24 h、白天、夜间平均收缩压/舒张 压显著下降，收缩压和舒张压的谷峰比值分别为0. 62和0.61。无严 重不良反应。结论贝尼地平是一种安全有效的抗高血压药。 【关键词】贝尼地平；原发性高血压；动态血压监测 Abstract: Objective To assess the clinical efficacy of benidipine on the trea tmient of essential hyppr tens ion by means of ambulatory blood pressure monitoring (ABPM)? Methods Fifty six patients with essential hypertension were selected, and randomly and double blindly divided into benidipine group (n=26) and irbesartan group (n=30)? Not only the changes in blood pressure before and after einght weeks9 drug treatment, but also the ambulatory blood pressure (24 hours for day and night) before and after the administration of benidipine were observed .Results In the patients who were administered wi th benidipine for eight weeks, the systolic blood pressure (SBP) and diastolic blood pressure (DPB) were depressed respectively by 16. 8 ± 11. 8 and 12. 8 ± 9. 2 (mmHg) (Pl t; 0. 01), and in those with irbesartan, the SBP and DBP were depressed by 14. 8 ± 10. 9 and 11. 2 ± 8. 7 (mmHg) (Pl t; 0. 01). ABPM for the 26 patients administered beidipine showed that benidipine reduced the average blood pressure significantly, and the mean trough to peak ratios were 0. 62 for SBP and 0. 61 for DBP? No severe bad react ion occurred? Conclusion 11 is suggested that benidipine is a safe and effective antihypertension drug? Key words : benidipine; essential hypertension; ambulatory blood pressure monitoring 贝尼地平是新型长效二氢毗唳钙离子拮抗剂，对血管平滑肌细胞 膜有很高的亲和性，它通过与阻断细胞膜电位依赖型钙离子通道的二 氢毗唳受体结合，阻止钙离子流入细胞内而使血管扩张。由于与结合 部位亲和性高，且解离速度非常缓慢，因而有长期而缓慢的降压作用。 本研究用动态血压监测的方法，比较贝尼地平和厄贝沙坦降压疗效和 安全性。 1材料与方法 1.1 一般资料 选择2006年1月一2008年3月我院门诊原发性高血压患者56 例，随机双盲接受贝尼地平（n=26）或厄贝沙坦（n=30）治疗8周， 贝尼地平组服药前后进行动态血压监测（ABPM）比较研究。 入选标准：26?79岁的