阿立哌唑治疗儿童精神分裂症对照研究.docVIP

阿立哌唑治疗儿童精神分裂症对照研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：阿立哌唑治疗儿童精神分裂症对照研究 1 1 对象与方法 2 2 结果 3 3 讨论 5 文2：阿立哌唑与利培酮治疗儿童精神分裂症对照研究 6 1 资料与方法 6 2 结果 7 3 讨论 7 参考文摘引言： 8 原创性声明（模板） 9 文章致谢（模板） 9 正文 阿立哌唑治疗儿童精神分裂症对照研究 文1：阿立哌唑治疗儿童精神分裂症对照研究 A control study of aripiprazole in the treatment of childhood schizophrenia 【Abstract】 Objective To explore the curative effect and safety of aripirazole in the treatment of childhood schizophrenia．Methods 50 patients with childhood schizophrenia were randomly divided into research(took aripirazole, n=25) and control group( did risperidone, n=25) for 8 weeks. Before treatment and at the ends of the 1st, 2nd, 4th, 6th and 8th week, curative effects were assessed with the Positive and Negative Syndrome Scale(PA) and advee effects with the Treatment Emergent Symptom Scale and the Scale for Extrapyramidal Side Effects(ES), respectively. Results At the end of 8th week, total effective rates were ％ in the research and 92％ in the control group respectively, the total effectiveness of the 2 groups was equivalent(χ2 = ,P)．Since the end of the 2nd week, the PA scores of both groups decreased very significantly compared with pretreatment(both P); at the end the 1st week, P score of the PA in the research group decreased more significantly than in the control group(P). Conclusion Aripiprazo1e has therapeutic equivalence to risperidone in childhood schizophrenia, relieves positive symptoms faster and has higher safety and better compliance. 【Keywords】 Aripiprazo1e ; rispehdone; childhood schizophrenia; the PA; the TESS 由于儿童正处于生长发育和学习阶段，当治疗儿童精神分裂症时要考虑其个体的特殊性。有报道［1］表明，利培酮治疗儿童精神分裂症疗效显著、安全性高。为此，作者应用阿立哌唑与其进行了临床治疗对照研究，以探讨阿立哌唑治疗儿童精神分裂症的疗效及安全性，现将结果报告如下。 1 对象与方法 对象 样本选自2004年12月～2005年12月在我院住院的儿童精神分裂症患者。入组标准：（1）符合《 中国 精神障碍分类与诊断标准》第3版(CCMD3)精神分裂症诊断标准［1］；（2）潘氏量表（PA）总分≥60分，年龄9 a～14 a，性别不限；（3）入院前未使用抗精神病药物治疗；（4）排除脑器质性疾病、精神发育迟滞及其他躯体疾病。符合上述入组条件者共50例，随机分为两组各25例。研究组男11例，女14例；平均年龄（±） a，平均病程（±） mo，平均住院时间（±） mo。对照组男10例，女15例；平均年龄（±） a，平均病程（±） mo