乌灵胶囊与美利曲辛治疗伴有焦虑症状的功能性消化不良对照研究.docVIP

乌灵胶囊与美利曲辛治疗伴有焦虑症状的功能性消化不良对照研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：乌灵胶囊与美利曲辛治疗伴有焦虑症状的功能性消化不良对照研究 1 1 对象与方法 3 2 结果 4 3 讨论 5 文2：乌灵胶囊莫沙必利与黛力新莫沙必利治疗功能性消化不良的对比 6 1 资料与方法 6 2 结果 8 3 讨论 9 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 乌灵胶囊与美利曲辛治疗伴有焦虑症状的功能性消化不良对照研究 文1：乌灵胶囊与美利曲辛治疗伴有焦虑症状的功能性消化不良对照研究 A control study of Wuling capsule and deanxit in the treatment of functional dyspepsia 【Abstract】 Objective To explore the efficacy and safety of Wuling capsule in the treatment of functional dyspepsia (FD) accompanied with mild to moderate anxiety. Methods 60 patients were randomly divided into 2 groups: Wuling capsule group (n=30，one dropped) treated with Wuling capsule and Deanxit group(n=30，four dropped) with Deanxit for 6 weeks. Clinical efficacy was assessed with the Hamilton Anxiety Scale (HAMA ) and the waterloading test and the sideeffects with the Treatment Emergent Symptoms Scale (TESS). Results After 6week treatment, scores of the HAMA of both 2 groups significantly reduced(P)，total effective rate of anxiety improvement were % and % respectively, water loading significantly increased (P), clinical efficacies were equivalent and side effects not significant. Conclusion Wuling capsule has significant effectiveness, high safety and well compliance in the treatment of FD accompanied with mild to moderate anxiety. 【Keywords】 Wuling capsule; deanxit; functional dyspepsia; anxiety 功能性消化不良（functional dyspepsia,FD）是消化系统的常见疾病。由于其发病原因复杂多样，发病机制尚未完全明确，目前多采用促动力、制酸和消化酶等制剂治疗，但疗效欠佳。近年来有报道表明［1］，精神心理因素与FD的发生密切相关。临床调查显示，≥70％的FD患者伴有焦虑或抑郁情绪。为此，我们采用乌灵胶囊与美利曲辛（黛力新）治疗伴有轻、中度焦虑的FD患者进行了对照研究，以探讨乌灵胶囊治疗FD的疗效及安全性，现将结果报告如下。 1 对象与方法 对象 选取在我院门诊治疗的60例FD患者为研究对象。入组标准：（1）均符合罗马Ⅱ标准的FD诊断标准［2］。（2）性别不限，年龄18～65a。（3）汉密顿焦虑量表（Hamilton Anxiety Scale,HAMA）评分12～24分。（4）入组前2w内未服用任何影响胃肠道动力的药物和抗焦虑、抑郁剂，如有用药，则进行2w清洗期。将入组病例随机分为两组各30例。研究组（乌灵胶囊治疗）失访1例，共完成研究29例，其中男12例，女17例，平均年龄±；对照组（美利曲辛治疗）失访4例，共完成研究26例，其中男10例，女16例，平均年龄±。两组性别、年龄均无显著性差异。 方法 药物治疗 研究组服用乌灵胶囊（浙江佐力药业有限公司）9粒#12539;d-1#12539;Tid。对照组顿服美利曲辛1片#1