LCT在宫颈癌和癌前病变筛查中的应用.docVIP

LCT在宫颈癌和癌前病变筛查中的应用 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：LCT在宫颈癌和癌前病变筛查中的应用 1 1 资料与方法 2 2 结果 4 3 讨论 5 文2：宫颈癌癌前病变筛查方法的综合评价 6 1 资料与方法 7 2 结果 7 3 讨论 8 参考文摘引言： 8 原创性声明（模板） 10 文章致谢（模板） 10 正文 LCT在宫颈癌和癌前病变筛查中的应用 文1：LCT在宫颈癌和癌前病变筛查中的应用 ［ABSTRACT］ObjectiveTo evaluate the accuracy of liquid-based technologies （LCT） for screening cervical carcinoma and precancerous change. MethodsFrom January 2003 to January 2005， 14 533 cases were screened for cervical carcinoma and pre-cancerous change with LCT or traditional cervical- cell smea . TBS-group system was adopted for cytologic diagnosis. A positive diagnosis， which included uatisfied samples and cases with atypical squamous cell of under mined significance （ASCUS） and a-bove， was examined with a colposcope. ResultsASCUS of LCT was significantly fewer than classical cervical smea （ χ2 = ，P ）. The positive rates of cervical precancerous lesion of LCT were higher than classical smea （ χ 2 =，P ）. The coincidence of LCT screening and classical smea with histologic-colposcopic results were significantly different be-tween the two methods （ χ2 =，; P ）. In the diagnosis of cervical cancer and precancerous lesion，the seitivity，specificity and positive rates of the LCT were higher than those of classical cervical smea （ χ2 = ，P ）. ConclusionCytologic examination of the cervix is an important diagnostic method for early cervical carcinoma and precancerous change. LCT is more propitious to reach this goal. LCT is superior to traditional one in detecting above-ASCUS pathological chan-ges with a higher seitivity， specificity and satisfied samples. ［KEY WORDS］cervix neoplasms; precancerous conditio; cytological techniques 宫颈癌及癌前病变是妇科最常见可治愈疾病，而采取有效检查方法，提高对宫颈病变的早期诊断率是治疗的关键。液基细胞学检测技术（LCT）于1999年获美国FDA批准应用于临床。其产品Au-to Cyteprep液基细胞学薄片可替代传统的宫颈巴氏涂片用于宫颈病变的筛查。本研究通过对比上述两种制片方法的诊断结果，并以组织病理学检查结果为标准，评价LCT在宫颈病变诊断中的临床应用价值。 1 资料与方法 对象 2003年1月～2005年1月，我院妇科门诊接受宫颈细胞学筛查妇女14 533例，年龄18～82岁。其中，采用传统涂片检查者7 300例（传统涂片组），采用LCT检查者7 233例（L