小儿川崎病并发冠状动脉病变高危因素探讨.docVIP

小儿川崎病并发冠状动脉病变高危因素探讨 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：小儿川崎病并发冠状动脉病变高危因素探讨 1 1 资料和方法 2 2 结果 4 3 讨论 5 文2：足月新生儿急性呼吸窘迫综合征发病的高危因素探讨 6 1 资料与方法 7 2 结果 8 3 讨论 9 参考文摘引言： 10 原创性声明（模板） 11 文章致谢（模板） 11 正文 小儿川崎病并发冠状动脉病变高危因素探讨 文1：小儿川崎病并发冠状动脉病变高危因素探讨 【ABSTRACT】 Objective: To investigate the relative rish facto for Kawasaki disease with complication of coronary artery disease. Methods: Restrospectively studied 86 children who suffered from the Kawasaki diseas. After investigating the clinical behavior,ultrasonic cardiograms and blood test results of acute prase(Including the Cholesterol、ESR、CRP、Platelet、Hemoglobin、Leucocyte),we analyzed the case by ttest and chiSquare test analysis. The incidence rate of coronary artery injury was 333% in cases who received IVIG therapy, while 642% in cases who only received aspirin therapy; but incidence rate of coronary artery injury was 96% in cases who received IVIG therapy within 7 days(P001). Results: Among 86 cases, the number of patients who got the complication of coronary artery disease was 26(30%). After analyzing the risk facto we find that fever duration、platelet、CRP、Cholesterol had Close relatiohip with the disease of coronary artery(P001). Conclusion: With help of medical analysis on the disease and combining the positive physical and laboratory findings,we can timely prediagnose the disease and give appropriate treatment in advance to prevent coronary artery disease and help the recovery of pathological changes for coronary artery； fulldose IVIG therapy in early stage can reduce the incidence of coronary artery injure. 【KEY WORDS】 Kawasaki disease; Coronary artery;Risk factor 川崎病（kawasaki disease, KD）又名皮肤粘膜淋巴结综合征，是一种原因不明确的儿童常见的自身免疫性血管炎综合征[1]。主要病理改变为全身非特异性血管炎，累及中小血管特别是冠状动脉，可形成冠状动脉瘤，引起血栓性梗塞、狭窄，导致心肌梗塞、猝死[2]。现对我院19961~20058月住院的86例KD患儿进行回顾性分析，旨在了解川崎病并发冠状动脉病变的危险因素，以便采取更好的措施，预防及减轻冠状动脉病变的发生，促进冠状动脉病变的恢复。 1 资料和方法 一般资料 根据第三届国际川崎病会议修订的诊断标准（1988年12月修订），我院儿科从19961~20058月收治KD患儿86例，男54例，女32例，男：女比例168∶1。年龄最小的6个