项八针联合吞咽康复训练对假性延髓麻痹吞咽 障碍患者血清VEGFTGF β1的影响.docxVIP

项八针联合吞咽康复训练对假性延髓麻痹吞咽 障碍患者血清VEGFTGF β1的影响 项八针联合吞咽康复训练对假性延髓麻痹吞咽障碍患者血清vegf、tgf-β1的影响 　　[摘要]目的探討项八针联合吞咽康复训练对假性延髓麻痹吞咽障碍患者血清vegf、tgf-β1的影响。方法选取2017年1月～2019年1月本院收治的假性延髓麻痹吞咽障碍患者136例，依据不同治疗方法分为观察组和对照组，各68例，两组均行常规药物治疗，对照组在此基础上采用项八针治疗，观察组采用项八针联合吞咽康复训练治疗，比较两组患者治疗前后标准吞咽功能评估（ssa）评分、电视透视吞咽功能检查（vfss）评分、血清血管内皮细胞生长因子（vegf）、转化生长因子-β1（tgf-β1）水平的差异，并统计临床疗效。结果观察组和对照组治疗前的ssa评分、vfss评分、vegf和tgf-β1水平比较，差异无统计学意义（p0.05）;治疗后，两组患者ssa评分较治疗前明显降低，vfss评分、vefg、tgf-β1水平较治疗前明显升高（p0.05）;观察组患者治疗后的临床有效率高于对照组（94.12%vs75.00%），差异有统计学意义（p0.05）。结论项八针联合吞咽康复训练能较好改善假性延髓麻痹吞咽障碍患者的吞咽功能，疗效优于单纯项八针治疗，其作用机制可能与调节血清vegf、tgf-β1的代谢、促进血管生成、保护神经元有关。 　　[关键词]项八针;吞咽康复训练;假性延髓麻痹;吞咽障碍;血管内皮细胞生长因子;转化生长因子-β1 　　[中图分类号]r246.6[文献标识码]a[文章编号]1673-9701（2020）09-0007-04 　　[abstract]objectivetoexploretheeffectofcervicaleight-needlecombinedwithswallowingrehabilitationtrainingonserumvegfandtgf-β1inpatientswithpseudobulbarparalysisdysphagia.methods136patientswithpseudobulbarparalysisdysphagiaadmittedtoourhospitalfromjanuary2017tojanuary2019wererandomlydividedintoobservationgroupandcontrolgroup，68casesineachgroup.bothgroupsweregivenroutinedrugtreatment.thecontrolgroupwasadditionallygivencervicaleight-needletreatment，andtheobservationgroupwasadditionallygivencervicaleight-needletreatmentcombinedwithswallowingrehabilitationtraining.thedifferencesofstandardswallowingfunctionassessment（ssa）score，tvfluoroscopyfunction（vfss）score，serumvascularendothelialgrowthfactor（vegf）andtransforminggrowthfactor-β1（tgf-β1）levelsbeforeandaftertreatmentwerecomparedbetweenthetwogroups.theclinicalefficacyofthegroupswasevaluatedandtheoccurrenceofadversereactionswasrecorded.resultsbeforetreatment，therewasnosignificantdifferenceinssascore，vfssscore，vegfandtgf-β1betweenthetwogroups（p0.05）.aftertreatment，thessascoresofthetwogroupsweresignificantlylowerthanthosebeforetreatment;thevfssscore，vefgandtgf-β1levelsweresignificantlyhigherthanthosebeforetreatment（p0.05）.thetotaleffectiverateoftheobservationgroupwassignificantlyhigherthanthatofthecontrolgroup（94.12