苯磺酸左旋氨氯地平和依那普利治疗老年单纯收缩期高血压的效果及对血管内皮细胞功能的影响.docxVIP

苯磺酸左旋氨氯地平和依那普利治疗老年单纯收缩期高血压的效果及对血管内皮细胞功能的影响 　　【摘要】目的：探讨苯磺酸左旋氨氯地平和依那普利治疗老年单纯收缩期高血压的效果及对血管内皮细胞功能的影响。方法：选取笔者所在医院2016年1月-2017年6月98例老年单纯收缩期高血压患者，按照随机数字表法分为对照组和观察组，每组49例。对照组给予依那普利治疗，观察组在对照组基础上采用苯磺酸左旋氨氯地平治疗。观察两组临床疗效、血管内皮细胞功能、血压及血压变异率。结果：观察组总有效率为93.88%，显著高于对照组的73.47%（p0.05）;两组治疗后et-1水平均较治疗前下降，且观察组显著低于对照组（p0.05）;两组治疗后no和fmd水平均较治疗前升高，且观察组显著高于对照组，差异均有统计学意义（p0.05）;观察组治疗后血压及血压变异率均低于治疗前及对照组，差异均有统计学意义（p0.05）。结论：苯磺酸左旋氨氯地平和依那普利治疗老年单纯收缩期高血压患者具有显著的临床效果，可以有效纠正血管内皮细胞功能，更好地控制血压并降低血压变异率，值得临床推广。 　　【关键词】苯磺酸左旋氨氯地平依那普利老年单纯收缩期高血压血管内皮细胞功能 　　[abstract]objective：toinvestigatetheefficacyoflevamlodipinebesylateandenalaprilinthetreatmentofelderlypatientswithsimplesystolichypertensionandtheeffectsonvascularendothelialcellfunction.method：atotalof98elderlypatientswithsimplesystolichypertensioninourhospitalfromjanuary2016tojune2017wererandomlydividedintothecontrolgroupandtheobservationgroup，49casesineachgroup.thecontrolgroupwastreatedwithenalapril，whiletheobservationgroupwastreatedwithlevamlodipinebesylateonthebasisofthecontrolgroup.theclinicalefficacy，vascularendothelialcellfunction，bloodpressureandbloodpressurevariabilitywereobservedbetweenthetwogroups.result：thetotaleffectiverateoftheobservationgroupwas93.88%，whichwassignificantlyhigherthan73.47%ofthecontrolgroup（p0.05）.aftertreatment，thelevelsofet-1inbothgroupsdecreasedcomparedwiththosebeforetreatment，andtheobservationgroupwassignificantlylowerthanthatofthecontrolgroup（p0.05）.aftertreatment，thelevelsofnoandfmdinbothgroupsincreasedcomparedwiththosebeforetreatment，andtheobservationgroupweresignificantlyhigherthanthoseofthecontrolgroup，andthedifferenceswerestatisticallysignificant（p0.05）.aftertreatment，thebloodpressureandbloodpressurevariabilityintheobservationgroupweresignificantlylowerthanthosebeforetreatmentandthecontrolgroup，andthedifferenceswerestatisticallysignificant（p0.05）.conclusion：levamlodipinebesylateandenalaprilinthetreatmentofelderlypatientswithsimplesystolichypertensionhavesignificantclinicaleffect，whichcaneffectivelycorrectth