医学免疫学课件：IL-33及其对肿瘤的效应.pptxVIP

IL-33及其对肿瘤的效应;报告提纲;报告提纲;IL-33;IL-1 家族;IL-33;IL-33结构;IL-33释放与调控;IL-33受体—ST2;IL-33与ST2的结合;IL-33;一/二型免疫反应;IL-33与一型免疫反应;报告提纲;IL-33对肿瘤的效应;报告提纲;乳腺癌血清IL-33水平;乳腺癌血清sST2水平;IL-33在乳腺癌细胞中的表达;IL-33促进乳腺癌生长;IL-33促进VEGF产生;血清VEGF水平;IL-33促进乳腺癌的机制;报告提纲;肺癌血清IL-33水平;肺癌细胞内IL-33水平;IL-33促进癌症细胞死亡;IL-33促进肺癌细胞死亡的机制;But, IL-33在肺癌中高表达;IL-33促进肿瘤生长;IL-33促进肿瘤生长的机制;报告提纲;肿瘤细胞内的IL-33;肿瘤组织内的ST2;IL-33/ST2促进肿瘤侵袭;IL-33促进结肠癌肝转移;IL-33招募淋巴细胞;IL-33破坏小肠上皮，高表达IL-6;IL-33促进促瘤细胞因子表达;But，IL-33抑制肿瘤生长;IL-33通过募集CTL抑制肿瘤生长;IL-33对肿瘤的效应;报告提纲;前景展望;参考文献;[10]. Yang, Z.P., et al., The Association of Serum IL-33 and sST2 with Breast Cancer. Dis Markers, 2015. 2015: p. 516895. [11]. Liu, J., et al., Significance of interleukin-33 and its related cytokines in patients with breast cancers. Front Immunol, 2014. 5: p. 141. [12]. Kim, J.Y., et al., Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity. Oncogene, 2015. 34(38): p. 4928-38. [13]. Kim, M.S., et al., Circulating IL-33 level is associated with the progression of lung cancer. Lung Cancer, 2015. 90(2): p. 346-51. [14]. Akimoto, M., et al., Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer. Cell Death Dis, 2016. 7: p. e2057. [15]. Wang, C., et al., IL-33 signaling fuels outgrowth and metastasis of human lung cancer. Biochem Biophys Res Commun, 2016. 479(3): p. 461-468 [16]. Islam, M.S., et al., Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells. Br J Pharmacol, 2016. 173(16): p. 2532-42. [17]. Mertz, K.D., et al., The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice. Oncoimmunology, 2016. 5(1): p. e1062966. [18]. Cui, G., et al., Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer. Cancer Immunol Immunother, 2015. 64(2): p. 181-90. ;[19]. Liu, X., et al., IL-33/ST2 pathway contributes to metast