人类遗传病人类遗传病 (2).pdfVIP

-I- W. Liu1l2, H. Wang1, S. Zhao3, W. Zhao4, S. The Novel Gene Locus for Bail, Y. Zhao5, S. Xu5, C. Wu5, W. Huang5, Z. Chen5, G. Feng1, and L. He 2* Agenesis of Permanent Teeth Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, P.R. (He-Zhaodeficiency) Maps China; 2Bio-X Life Science Research Center, PO Box 501, Hao Ran Building, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China; 3Junior Middle School ofXunyi County, to Chromosome 1 Oq 11.2 Shanan Xi province, P.R. China; 4Hospital ofXunyi County, Shanan Xi province, P.R. China; and 5Chinese National Human Genome Center at Shanghai, Shanghai, P.R. China; *corresponding author, helinanna@ J Dent Res 80(8):1716-1720, 2001 ABSTRACT INTRODUCTION He-Zhao deficiency has been recently Tooth agenesis (one or more teeth missing) is one of the most common characterized with a distinct form of agenesis of developmental abnormalities in the human. Tooth agenesis may be of permanent teeth that is different from other familial or sporadic origin. More than 20% of the population is affected by previously reported disorders of tooth agenesis. wisdom tooth deficiency. Incidences of the other tooth agenesis vary from This inherited abnormality suggests that some 1.6% to 9.6% (McKusicket al., 1998). In fact, there are about 100 inherited gene(s) associated with the development of disorders or syndromes related to the congenital absence of one or more permanent teeth may mutate. In this study, we teeth. The mode of inheritance can be autosomal-dominant, -recessive, or map the gene locus to chromosome lOqi 1.2. The X-linked. The disorders can occur in primary or permanent teeth, with DNA poolin