动脉硬化血栓病理生理学.pptxVIP

动脉硬化血栓病理生理学第1页/共40页 What Is Atherothrombosis?The formation of a thrombus on an existing atherosclerotic plaqueAtherothrombosis is a new term recognizing that atherosclerosis (plaque development) and acute thrombosis are integrally related to the presentation of vascular events A generalized progressive disease of large- and mid-size arteries that affects multiple vascular beds, including cerebral, coronary, and peripheral arteries The underlying disease leading to myocardial infarction (MI), peripheral arterial disease (PAD), ischemia and many forms of strokeMI, myocardial infarction; PAD, peripheral artery disease.Fuster V, et al. Vasc Med. 1998;3:231-239.Rauch U, et al. Ann Intern Med. 2001;134:122-238.第2页/共40页 Atherothrombosis* is theLeading Cause of Death Worldwide1* Atherothrombosis defined as ischemic heart disease and cerebrovascular disease.1 The World Health Report 2001. Geneva. WHO. 2001.22.319.312.69.796.3051015202530Atherothrombosis*Infectious DiseaseCancerInjuriesPulmonary DiseaseAIDSCauses of Mortality (%)第3页/共40页 Atherothrombosis Significantly Shortens LifeAnalysis of data from the Framingham Heart Study.Peeters A, et al. Eur Heart J. 2002;23:458-466.Atherothrombosis reduces life expectancy by around 8-12 years in patients aged over 60 years1Average Remaining Life Expectancy at Age 60 (Men)048121620HealthyYearsHistory of AMI-9.2 yearsHistory of Cardiovascular Disease-7.4 yearsHistory of Stroke-12 years第4页/共40页 3.2 Million Hospital AdmissionsCoronary Atherosclerosis Acute Myocardial Infarction1,153,000 Admissions829,000 AdmissionsHospitalizations in the USDue to Vascular DiseaseCerebrovascular Disease961,000 AdmissionsVascular DiseaseOther IschemicHeart Disease280,000 AdmissionsPopovic JR, Hall MJ. Advance Data. 2001;319:1-20.第5页/共40页 Preventable DeathsApproximately 57,000 deaths could be avoided each year in the US if patients were given appropriate care. National Committee for Quality Assurance. Washington, DC 2003.700Cervical-cancer scree