分子生物学工作基础.pptxVIP

分子生物学工作基础第1页/共47页 Human Genome ProjectGoals:?■ identify all the approximate 30,000 genes in human DNA, ■ determine the sequences of the 3 billion chemical base pairs that make up human DNA, ■ store this information in databases, ■ improve tools for data analysis, ■ transfer related technologies to the private sector, and ■ address the ethical, legal, and social issues (ELSI) that may arise from the project. ?Milestones:■ 1990: Project initiated as joint effort of U.S. Department of Energy and the National Institutes of Health ■ June 2000: Completion of a working draft of the entire human genome (covers 90% of the genome to a depth of 3-4x redundant sequence) ■ February 2001: Analyses of the working draft are published■ April 2003: HGP sequencing is completed and Project is declared finished two years ahead of scheduleU.S. Department of Energy Genome Programs, Genomics and Its Impact on Science and Society, 2003http://www.sanger.ac.uk/HGP/overview.shtml第2页/共47页 3Dr. Francis CollinsFrancis Sellers Collins (born April 14, 1950), is an American physician-geneticist, noted for his discoveries of disease genes and his leadership of the Human Genome Project (HGP). He currently serves as Director of the National Institutes of Health in Bethesda, Maryland. Collins accepted an invitation in 1993 to succeed James D. Watson as Director of the National Center for Human Genome Research, which became National Human Genome Research Institute (NHGRI) in 1997. As Director, he oversaw the International Human Genome Sequencing Consortium./glossary/index.cfm?id=528第3页/共47页 4Dr. Craig Venter In 1998, Dr. Venter founded Celera Genomics and announced that Celera would decode the human genome faster and more economically than the publicly funded consortium of scientists. That challenge is now credited with creating the climate of urgency that spurred competition and substantially accelerated the project’s successful conclusion. Dr. Venter founded the J. Craig Venter Institute, and he is n