医学免疫学课件-免疫学概论.pptVIP

CAMS/PUMC 1959～ Bunet, Medawar The elegant and simple version of the SNSD model 识别自身与非己理论 CAMS/PUMC 1969~ Brestche, Langman and Cohn MHC-peptide CD40-CD40L IL-2,IL-4,IL-5 识别自身与非己理论 Associative Recognition model: Two Signal model CAMS/PUMC 1974～Lafferty and Cunningham 识别自身与非己理论 Costimulatory model CAMS/PUMC 1989～Charlie Janeway Binding bacteria to PRRs induce activation activation of APCs Two different types of nonself recognition A genetically encoded set of PRRs assigned to the cells and molecules of the innate immune system a somatically generated set of receptors expressed by the cells of adaptive immune system 识别自身与非己理论 CAMS/PUMC Danger model 1994～ Polly Matzinger Activation state of an APC depends on the health of the cells in its neighbourhood Injured (distressed) cells, namely cells that are abnormally distressed, damaged, die an abnormal death, or are destroyed necrotically, should activate their local APCs A foreign entry that does no injury should not evoke a response,regardless of abnormality of physiology that cause stress or injury to a tissues could kindle a response in the absence of any foreignness CAMS/PUMC PAMPs and PRRs 1989~ Charlie Janeway Binding bacteria to PRRs induce activation of APCs Two different types of nonself recognition A genetically encoded set of PRRs assigned to the cells and molecules of the innate immune system a somatically generated set of receptors expressed by the cells of adaptive immune system CAMS/PUMC * In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity. Pathogen-Associated Molecular Patterns (PAMPs) The surfaces of microorganisms typically bear repeating patterns of molecular structure Pattern Recognition Receptors (PRRs) CAMS/PUMC CAMS/PUMC T细胞 CAMS/PUMC T辅助细胞（TH） CD4 TH细胞协调免疫应答 CAMS/PUMC CD4+ T cell subsets IL-12 and IFN-g Th1 Th2 Th17 Treg IL-4 IL-6 and TGFb TGFb IL-2,IFNg, TNFa IL-4,IL