原发性支气管肺癌中英文对照.pptxVIP

原发性支气管肺癌中英文对照第1页/共82页 2定义Definition原发性支气管肺癌简称肺癌，是起源于支气管粘膜或腺体的肿瘤。Primary bronchogenic carcinoma is abbreviated to lung cancer, it derives from bronchi mucosa or gland.第2页/共82页 3EpidemiologyLung CancerWorldwide: most common cancer2,000,000 cases per yearChina : first leading cause of cancer death in urban area15% 5-year survival第3页/共82页 4病因和发病机制Etiology and pathogenesis1 吸烟1 Smoking第4页/共82页 5Lung Cancer: Smoking FactsTobacco use is the leading cause of lung cancer87% of lung cancers are related to smokingRisk related to:Amount smoked Age of smoking onsetProduct smoked (tar/nicotine content, filters)Depth of inhalationGenderRisk goes down after 5 yrs cessationAt 15 years, 80-90% risk reductionNever gets to “never smoker” risk第5页/共82页 620 Year Lag第6页/共82页 7 If what happened on your inside happened on your outside, would you still smoke?第7页/共82页 82 职业致癌因子2 Occupation carcinogenic factor: Asbestos, Radon 3 空气污染3 Air pollution（1）室外大环境污染（1）Outdoor environment pollution（2）室内小环境污染（2）Indoor environment pollution4 电离辐射4 Ionizing radiation第8页/共82页 95 饮食与营养5 Diet and nutritionVITAMIN A???????????????????第9页/共82页 106 其他因素6 Other factors 7 遗传因素7 Hereditary factorTumor suppressor genes *p53Dominant oncogenes *Kras *Her-2/neu第10页/共82页 11病理和分类Pathology and classification第11页/共82页 12解剖学分类Anatomy classification1 中央型肺癌1 Central lung cancer第12页/共82页 132 周围型肺癌2 Peripheral lung cancer第13页/共82页 14组织学分类Histology classification1 小细胞肺癌1 Small cell lung cancer, SCLC（1）燕麦细胞型（1）oat cell type（2）中间细胞型（2）intermediate cell type（3）混合型（3）mixed type第14页/共82页 15Small cell carcinomaRare in non-smokersLarge hilar mass 70% present with overt metastasisVery chemo-responsive…Worst prognosis第15页/共82页 16Small cell carcinoma第16页/共82页 172 非小细胞肺癌2 Non-small cell lung cancer, NSCLC（1）鳞状细胞癌（鳞癌）（1）Squamous cell carcinoma, SCC（2）腺癌和支气管肺泡癌（2）Adenocarcinoma，AC，and bronchoalveolar carcinoma（3）大细胞癌（3）Large cell carcinoma（4）鳞腺癌（4）Adeno-squamous carcinoma第17页/共82页 18Squamous cell carcinomaNow 2nd most common ( 1