附子化学成分和药理作用研究进展.docxVIP

Guihaia D ec. 2017 , 37(12) : 1614- 1627 http ://www.guihaia-j ournal .com DOI: 10.11931/guihaia.gxzw201704033 :Z ,L ,Ml .hia ii1e 1d:ia [ J] . Guihaia , 2017 , 37( 12) : 1614- 1627 附子化学成分和药理作用研究进展 唐 梅 1 , 赵立春 1 , 2 ?, 徐 敏2 , 冷 静 1 , 唐 农 1 , 扈芷怡 1 , 张谦华 1 ( 1 . 广西中医药大学，南宁 530299; 2. 香港浸会大学 中医药学院，香港 999077 ) 摘 要：通过查阅国内外文献，对附子的化学成分及药理作用进行了综述 。结果表明：附子中主要含有生 物碱成分，经分离鉴定的有百余个，主要骨架类型为 C? 19 型二萜生物碱；其次为 C?20 型二萜生物碱，除生 物碱以外，还含有黄酮、多糖、甾醇、有机酸等化学成分 。附子的药理作用研究已久，主要有对心血管的作 用、镇痛抗炎作用、免疫调节作用、抗肿瘤作用、抗衰老作用、降低胆固醇作用等 。附子有“ 回阳救逆第一 品 药”之称，为广泛应用的有毒中药，目前临床观测附子毒副反应的项目及其标准既不系统，也不明确，还没有 实用的指南对其进行安全性监控 。对附子的化学成分和药理作用进行全面系统地整理，期待在转化研究的 启发下，运用代谢组学等新技术为附子应用的安全性评价带来突破，使其能更好地服务于临床。 关键词：附子，化学成分，C ? 19 型二萜生物碱，药理作用，代谢组学 中图分类号：Q946 文献标识码：A 文章编号：1000?3142( 2017)12? 1614? 14 Chemical constituents and pharmacological activities of Aconiti lateralis Radix Praeparata TANG Nong1 , HU Zhi?Yi1 , ZHANG Qian?Hua1TANG Mei1 , ZHAO TANG Nong1 , HU Zhi?Yi1 , ZHANG Qian?Hua1 (1. Guangxi University ofChinese Medicine , Nanning 530299 , China; 2. School ofChinese Medicine , Hong Kong Baptist University, Hongkong 999077 , China ) Abstract: Researches on chemical constituents and pharmacological activities of Aconiti Lateralis Radix Praeparata in re? cent years are reviewed , classified and analyzed. The main constituents of this traditional Chinese medicine were alka? loids , among which C? 19 diterpenoid alkaloids were the leading compounds , followed by C?20 diterpenoid alkaloids , in addition to alkaloids , there were flavonoids , polysaccharides , sterols , organic acids , et al. Modern pharmacological re? searches demonstrated that these compounds or plant extracts showed cardiovascular, analgesic , anti?inflammatory, im? mune regulation, anti?tumor, anti?senility and cholesterol lowering effects. A. lateralis Radix Praeparata, the widely used toxic traditional Chinese medicine , the proj ects and standards of its clinical observation of toxic effects were neither sys? tematic nor clear,