两种处方饮食对2型糖尿病患者血脂及胰岛素抵抗的影响.docVIP

GIP Chinese General Practice 2011年1月第14卷第1B期 · 133 · · 论 著 · 两种处方饮食对2型糖尿病患者血脂及胰岛素抵抗的影响 华鑫，洪忠新 【摘要】 目的 探讨个体化处方饮食与单一处方饮食对2型糖尿病 (T2DM) 患者血脂及胰岛素抵抗的影响。 方法 将209例 T2DM 患者随机分为对照组(88例)和试验组(121例),试验组患者实行个体化处方饮食+胰岛素 治疗，对照组患者实行单一处方饮食+胰岛素治疗。比较两组患者治疗前后血脂[三酰甘油 (TG)、 总胆固醇 (TC)、 高密度脂蛋白胆固醇 (HDL-C)、 低密度脂蛋白胆固醇 (LDL-C)]、 空腹血糖 (FPG)、 空腹胰岛素 (FINS) 水平及 胰岛素抵抗指数 (HOMA-IR) 。 结果 治疗前两组患者血脂、 FPG 、FINS 水平及 HOMA-IR 比较，差异均无统计学 意义 (P0.05); 治疗后试验组患者血脂、 FPG 水平及 HOMA-IR 均显著低于对照组，差异有统计学意义 (P 0.05),而FINS 间差异无统计学意义 (P0.05)。 治疗前后T2DM 患者血清TG 水平与HOMA-IR 均呈正相关 (P 0.05)。结论 给予T2DM 患者个体化处方饮食可降低血脂及胰岛素抵抗程度。 【关键词】 糖尿病膳食；糖尿病，2型；血脂；胰岛素抵抗 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2011)01-0133-03 Ef fects of Individualized Prescriptive Diet and Single Prescriptive Diet on Blood Lipids and Insulin Resistance in Type 2 Diabetes Mellitus Patients HUA Xin, HONG Zhong-xin. Department of Nutrition,Beijing Friendship Hospital,Capital Uni- versity of Medical Sciences,Beijing 100050,China 【Abstract] Objective To explore the effects of individualized prescriptive diet(IPD)and single prescriptive diet (SPD) on blood lipids and insulin resistance in type 2 diabetes mellitus(T2DM)patients. Methods Totally 209 T2DM pa- tients were randomly divided into IPD group and SPD group. Insulin treatment was provided in both groups. The levels of blood lipid profiels(TG,TC, HDL-C),and LDL-C, fasting plasma glucose(FPG), fasting insulin(FINS),and insuline re- sistance index(HOMA -IR) were compared in both groups before and after treatment. Results The baseline data were not sig- nificantly different between IPD group and SPD group(all P0.05). After the treatment,blood lipids,EPG,and HOMA- IR were significantly lower in IPG group than in SPD group(all P0.05),although FINS showed no significant difference(P 0.05). The serum TG levels in T2DM patients before and after treatment were positively correlated with HOMA-IR(both P 0.05). Conclusion IPD can effect