流式细胞术观测松龄血脉康对糖尿病患者血小板活化状态的影响.docVIP

GIP Chinese General Practice 2010年10月第13卷第10C期 · 3453 · · 中 西 医 结 合 研 究 · 流式细胞术观测松龄血脉康对糖尿病患者 血小板活化状态的影响 潘永源，王立 【摘要】 目的 观察松龄血脉康对糖尿病患者血小板活化状态的影响。方法 选取140例血糖控制平稳的糖尿 病患者，将其随机分为阿司匹林组(50例)、松龄血脉康组(50例)及对照组(40例);另选取25例健康者作为正 常对照组。糖尿病患者在原有血糖控制治疗的基础上，阿司匹林组和松龄血脉康组分别给予阿司匹林或松龄血脉康治 疗，对照组不加用药物。利用流式细胞仪测定糖尿病患者及健康者用药前及用药1周、4周后血小板活化的标志物 —-血小板膜糖蛋白Ⅱb/Ⅲa 纤维蛋白原受体 (PAC-1) 的活性，并与正常对照组比较。结果 用药前糖尿病患者血 糖控制平稳后PAC-1 活性仍较正常对照组显著升高，经阿司匹林或松龄血脉康治疗1周、4周时PAC-1 活性较用药 前显著降低，较对照组治疗后的PAC-1 活性亦显著降低，差异均有统计学意义 (P0.05)。 结论 即使糖尿病患者 血糖控制平稳，其血小板活化率仍然高于健康者；松龄血脉康治疗可以降低糖尿病患者的血小板活化程度，其作用与 阿司匹林相当。 【关键词】 流式细胞术；糖尿病，2型；血小板活化；血小板聚集抑制剂；阿司匹林；中成药 【中图分类号】 R587.1。 【文献标识码】 A 【文章编号】1007-9572(2010)10-3453-03 Eff ect of Songling Xuemaikang on Platelet Activation in Diabetic Patients Detected by Flow Cytometric Analysis PAN Yong-yuan, WANG Li. Department of Endocrinology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China 【Abstract] Objective To observe the effect of Songling Xuemaikang on platelet activation in diabetic patients. Meth- ods PAC- 1,the marker of platelet activation, was detected by flow cytometric analysis in 140 diabetic patients, which were randomized into Aspirin group(n=50),Songling group(n=50)and control group(n=40). Control group was not given any drug. PAC- 1 was measured on 7th, 28th day and was compared with that of normal adults group (n=25). Results PAC- 1 in diabetics remains significantly higher after glucose adjusted to a normal level. Treatment with Aspirin and Songling Xuemai- kang can reduce PAC- 1 level significantly. The level of PAC- 1 was significantly reduced compared with that of the control group(P0.05). Conclusion Platelet -activated ratio is high in diabetic patients, and remains higher than the normal peo- ple even if glucose can be well controlled. Aspirin and Songling Xuemaikang can lower platelet - activated ratio of diabetics al- most to a normal level. And their effect is pretty much the same. 【Key words 】 Flow cytometry;