前列地尔治疗Ⅳ期糖尿病肾病的疗效观察.docVIP

·1388 · · 短 篇 论 著 · 前列地尔治疗IV 期糖尿病肾病的疗效观察 陆 帅 ， 王 娟 【摘要】 目的 观察前列地尔治疗IV期糖尿病肾病 (DN) 的疗效。方法 选取2011年2— 12月在我院内分泌 科住院的IV期 DN 患者78例，随机分为对照组(38例)和前列地尔组(40例)。两组均常规给予糖尿病饮食、运动及 降血压、降血脂、降血糖治疗；待患者血糖、血脂、血压稳定1周后，前列地尔组另给予前列地尔20 μg 加入0 .9%氯 化钠注射液100ml 中静脉滴注，1次/d,7d 为1个疗程。比较治疗前及治疗3个月后两组患者的血压、糖化血红蛋 白、血脂、血尿素氮、血清肌酐、尿清蛋白定量及血β2微球蛋白(β2-MG) 水平。两组间比较采用成组t检验。结 果 治疗前两组患者血压、糖化血红蛋白、血脂、血尿素氮、血清肌酐、尿清蛋白定量、血β2-MG水平比较，差异 均无统计学意义 (P0.05); 治疗后前列地尔组患者尿清蛋白定量和血β2-MG 水平低于对照组〔尿清蛋白：(343 ±61)mg/24 h与(366±54) mg/24 h; 血β2-MG(458±107)mg/24 h与(471±111) mg/24 h], 差异均有统计学 意义 (P0.05)。 结论 静脉应用前列地尔治疗IV期 DN 惠者，短期能减少患者尿清蛋白量和血β2-MG 水平，从而 改善 DN 患者的预后。 【关键词】 前列地尔；糖尿病肾病；尿清蛋白；β2微球蛋白 【中图分类号】 R587.24 【文献标识码】 B doi:10.3969/j.issn.1007-9572.2013.04.096 陆帅，王娟.前列地尔治疗IV期糖尿病肾病的疗效观察 [J]. 中国全科医学，2013,16(4):1388 -1390. [www.chinagp. net] Effect of Alprostadil on Patients with Diabetic Nephropathy of Stage IV LU Shuai,WANG Juan. Department of Endocrinol- ogy,Chongming Branch of Xinhua Hospital, Shanghai Jiaotong University School of Medicine,Shanghai 202150,China 【Abstract 】 Objective To investigate the effect of alprostadil on patients with diabetic nephropathy(DN) of stage IV. Methods 78 DN patients at stage IV admitted to endocrine department of our hospital from February to December in 2011 were randomly divided into control group(38 cases)and alprostadil group (40 cases).The two groups were both given diabetic di- ets, treatment of exercise, antihypertension,antilipidemic and antidiabetics. The alprostadil group was given 20 μg alprostadil in 100 ml 0.9% sodium chloride injection one time a day for 7 days. The blood pressure, HbA,o, blood lipid, blood urea nitrogen, serum creatinine,24 h urinary albumin and β2-microglobulin(β2-MG)were compared between the two groups before treat- ment and three months after treatment. t test was used in the comparison. Results The blood pressure, HbA,o, blood lipid, blood urea nitrogen, serum creatinine,24 h urinary albumin and β2 - MG showed no statistically significa