血清1,25-二羟维生素D_3水平与糖尿病肾病的关系研究.docVIP

·3936 · YGPChinee General Practice December 2011, VoL14 No.12A · 论 著 · 血清1,25-二羟维生素 D, 水平与糖尿病肾病的关系研究 谷丽娟，刘建萍，霍亚南，刘精东 【摘要】 目的 探讨血清1,25-二羟维生素D? 水平与2型糖尿病 (T2DM) 的关系及其在糖尿病肾病 (DN) 发生发展中的意义。方法 选择64例2型糖尿病患者和20名正常对照者，根据尿清蛋白肌酐比值 (ACR) 及血肌酐 值将糖尿病患者分为糖尿病正常蛋白尿组、微量蛋白尿组、大量蛋白尿组及肾功能不全组。采用 ELISA 法测定血清 1,25-二羟维生素D? 水平，同时常规测定血糖、血脂、糖化血红蛋白、肌酐、血钙、血磷、体质指数及胰岛素等指 标。结果 (1)2型糖尿病组的血清1,25-二羟维生素D3 水平明显低于正常对照组，差异有统计学意义 (P 0.05)。(2)正常蛋白尿组、微量蛋白尿组、大量蛋白尿组及肾功能不全组的血清1,25-二羟维生素D? 水平逐渐降 低，组间比较差异均有统计学意义 (P0.05)。(3) 血清1,25-二羟维生素D, 与体质指数、血肌酐、胰岛素抵抗指 数(HOMA-IR) 呈负相关 (P0.05)。 结论 血清1,25-二羟维生素D; 水平可能与2型糖尿病及糖尿病肾病相关， 可能是2型糖尿病和糖尿病肾病发生发展中的重要因素。 【关键词】 糖尿病肾病；糖尿病，2型；1,25-二羟维生素D? 【中图分类号】 R587.24 【文献标识码】 A 【文章编号】1007-9572(2011)-3936-04 Relationship between Serum 1, 25- Dihydroxyvitamin D3 and Diabetic Nephropathy GU Li -juan,LIU Jian -ping, HUO Ya-nan,et al. Peoples Hospital of Fengcheng of Jiangxi Province,Fengcheng 331100,China 【Abstract】 Objective To explore the association of serum 1, 25 -Dihydroxyvitamin D; level with type 2 diabetes mellitus(T2DM)and its role in development of diabetic nephropathy(DN).Methods Totally 64 T2DM patients and 20 healthy subjects were recruited. The patients were further divided as groups of non - albuminuria,micro -albuminuria,poly- albuminuria,and renal insufficiency according to the urinary albumin to creatinine ratio(ACR)and serum creatinine level. The level of serum 1, 25-Dihydroxyvitamin D3 was detected by enzyme linked immunosorbent assay (ELISA),and the levels of blood glucose,lipid,glycosylated hemoglobin(HbA,e), creatinine,calcium, phosphorus, body mass index,and insulin were measured. Results (1)The T2DM patients had lower serum 1, 25- Dihydroxyvitamin D3 levels than healthy subjects and the difference was statistically significant(P0.05).(2)Serum 1, 25-Dihydroxyvitamin D; levels of the four groups were gradually decreased and significant differences were observed (P0.05).(3)Serum 1,25-Dihydroxyvitamin D, levels was negatively correla