妊娠期糖尿病孕妇及胎儿胰岛素与游离脂肪酸分析.docVIP

·1874 · · 论 著 · 妊娠期糖尿病孕妇及胎儿胰岛素与游离脂肪酸分析 朱自强，曹芳，黄瑞萍，虞斌，王慧艳，王新红，张铭，王秋伟 【摘要】 目 的 了解妊娠期糖尿病 (GDM) 孕妇及胎儿的胰岛素、血糖与血脂情况。方法 选取我院定期产检 并住院分娩的GDM 孕妇，并经饮食控制至正常血糖水平的81例作为GDM 组，对照组健康孕妇86例；以及对应的 GDM 母亲胎儿脐血65 例及正常孕妇胎儿脐血47例。采用生化分析仪检测母血清及脐血的血糖、游离脂肪酸 (NEFA)、 总胆固醇 (TC) 和三酰甘油 (TG) 水平，电化学发光法检测母血清及脐血胰岛素。结果 (1) GDM 孕妇 与正常孕妇相比，血糖、 TG、TC 与 NEFA 间差异无统计学意义 (P0.05); 但是胰岛素水平〔(25±15) mU/L 比 (15±8)mU/L〕 差异有统计学意义 (P0.05)。(2)GDM 孕妇胎儿和正常孕妇胎儿相比，脐血血糖、 TG 与 TC 水平 差异无统计学意义 (P0.05), 但 NEFA〔(0.19±0.08)mmol/L 比(0.15±0.05)mmol/L〕、 胰岛素〔(15±13) mU/L 比(8±4) mU/L〕 水平差异有统计学意义 (P0.05)。 结论 经血糖控制的 GDM 孕妇，虽然血糖与血脂均正 常，但仍存在高胰岛素血症；并且其胎儿的胰岛素与NEFA 水平升高，这可能是GDM 孕妇子代易发生糖尿病等代谢性 疾病的重要因素。 【关键词】 糖尿病，妊娘；胰岛素；脂肪酸类，非酯化；胎儿 【中图分类号】 R587.1 【文献标识码】 A doi:10.3969/j.issn.1007-9572.2013.06.018 朱自强，曹芳，黄瑞萍，等.妊娠期糖尿病孕妇及胎儿胰岛素与游离脂肪酸分析 [J]. 中国全科医学，2013,16 (6):1874- 1876.[] Fe tal and Maternal Levels of Insulin and Free Fatty Acid in Pregnant Women with Gestational Diabetes Mellitus ZHU Zi-qiang, CAO Fang, HUANG Rui-ping, et al. Changzhou Women and Children Health Hospital Affiliated to Nanjing Medical University, Changzhou 213003,China 【Abstract】 Objective To explore the fetal and maternal levels of insulin,glucose and lipid in pregnant women with gestational diabetes mellitus(GDM). Methods Eighty -one and 86 maternal blood samples,and 65 and 47 venous cord blood samples were collected from 81 well - controlled GDM mothers and 86 healthy mothers. The blood glucose, free fatty acids (NEFA),total cholesterol(TC), and triglyceride(TG)levels of the blood samples were measured with automatic biochemical analyzer. The insulin levels were measured with electrochemiluminescence method. Results The blood glucose,TG, TC,and NEFA were not significantly different between the well- controlled GDM mothers and the healthy mothers(P0.05), but the insulin level of the CDM group was higher than that of the healthy group 〔(25±15)mU/L vs.(15±8)mU/L;P0.05 〕. The fetal levels of blood glucose,TG, and TC were not si