阿卡波糖对不同性别2型糖尿病患者治疗效果的比较研究.docVIP

· 1701 · · 论 著 · 阿卡波糖对不同性别2型糖尿病患者治疗效果的比较研究 李丽，刘苗，李静，廉莹，赵宏，单忠艳，滕卫平 【摘要】 目的 探讨阿卡波糖对不同性别2型糖尿病 (T2DM) 患者降血糖效果的差别。方法 选取新诊断的 T2DM 患者48例，其中男27例，女21例。均给予阿卡波糖(拜唐苹)治疗。监测并比较治疗前、治疗3个月、6个 月时男性与女性患者的体质指数、腰臀比、血压、血脂、糖化血红蛋白 (HbA,e)、 空腹血糖 (FBG) 及餐后30、120、 180 min血糖和胰岛素水平。结果 HbA,。:治疗3个月、6个月时，男性HbA。 下降幅度均显著大于女性，差异有统计 学意义 (P0.05)。 血糖：治疗前男性及女性患者各时间点的血糖水平间差异无统计学意义 (P0.05); 治 疗 3 个 月、6个月时男性与女性血糖下降幅度间差异亦无统计学意义 (P0.05)。 胰岛素：治疗6个月时男性和女性各时点 (除外女性餐后30、180 min 时)胰岛素水平均较治疗前显著下降 (P0.05), 但男性与女性下降幅度间比较，差异并 无统计学意义 (P0.05)。 结论 阿卡波糖能降低 FBG、 餐后血糖及HbA,。, 改善胰岛素抵抗。 HbA,。下降幅度与性别 有关，男性下降更明显。 【关键词】 糖尿病，2型；性别；阿卡波糖；治疗结果 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2012)05-1701-04 Effective of Acarbose in Treating Patients with Type 2 Diabetes: Comparison between Men and Women LI Li, LU Mi- ao,L Jing, et al. Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affliated Hospital,Chi- na Medical University, Shenyang 110001,China 【Abstract] Objective To explore the effectiveness of acarbose in treating male or female patients with type 2 diabetes mellitus(T2DM). Methods A total of 48 newly confirmed T2DM patients were divided into male group(n=27)and female group(n=21). Both groups were treated with acarbose. Their body mass index(BMI), weight-height ratio(WHR), blood pressure, blood lipid, HbA, and FBC as well as blood glucose and insulin levels 30, 120 and 180 minutes after meals were determined or calculated before treatment and 3 and 6 months after treatment. Results The decrease amplitude of HbA,e in male patients was significantly larger in females than in males after 3 and 6 months treatment(P0.05). Blood glucose showed no significant difference at different time points(P0.05),and the amplitude of decrease three months after treatment was also not significantly diferent from that after six months. The insulin levels in both male and female groups obviously decreased at after treatment, but the difference in the amplitude of