不同程度糖尿病足溃疡风险患者血浆胰岛素样生长因子1水平的变化及意义.docVIP

GP Chinese General Practice ·1632 · May 2011.Vol,14 No.5C · 专 题 研 究 · 不同程度糖尿病足溃疡风险患者血浆胰岛素样生长因子1 水平的变化及意义 王晓丽，常向云，孙侃 【摘要】 目的 探讨不同程度糖尿病足溃疡风险患者血浆胰岛素样生长因子1 (IGF-1) 水平的变化及其意义。 方法 选取2型糖尿病患者126例，其中糖尿病足溃疡高度风险组25例，中度风险组32例，轻度风险组30例，无风 险组39例，另设正常对照组20例，测定临床生化指标及血浆IGF-1 水平。结果 糖尿病各组血浆IGF-1 水平均低 于正常对照组，差异均有统计学意义 (P0.05), 糖尿病足溃疡高度风险组患者血浆ICF-1 水平明显低于轻度风险 组及无风险组，差异均有统计学意义 (P0.05)。 血浆IGF-1 水平与病程、糖化血红蛋白 (HbA,e)、24 h尿蛋白定 量呈负相关 (P0.05)。 结论 糖尿病患者血浆IGF- 1 水平下降可能与糖尿病足溃疡风险增加有重要关联。 【关键词】 糖尿病，2型；糖尿病神经病变；胰岛素样生长因子1 【中图分类号】 R587.25 【文献标识码】 A 【文章编号】1007-9572(2011)05-1632-03 Changes of Plasma Insulin Like Growth Factor 1 in Patients with Different Risks of Diabetic Foot Ulcers and Their Si g- nificance WANG Xiao - li, CHANG Xiang - yun, SUN Kan. Department of Endocrinology, the First Affliated Hospital, School of Medicine of Shihezi University, Shihezi 832000,China 【Abstract] Objective To explore the changes of insulin like growth factor 1(IGF- 1) in patients with different risks of diabetic foot ulcers. Methods The clinical biochemical indices and plasma IGF - 1 levels were determined in 126 diabetic patients divided into groups high-risk(n=25),moderate -risk(n=32),mild-risk(n=30),non-risk(n=39),and in control group (n=20). Results The levels of plasma IGF- 1 were significantly lower in diabetic groups than in control group(P0.05),and in high -risk group than in groups mild - risk and non-risk(P0.05). Plasma ICF- 1 was nega- tively correlated with courses of diseases, HbA,e, 24 h urine protein excretion(P0.05). Conclusion The decrease of plas- ma IGF- 1 may increase the risk of diabetic foot ulcer. 【Key words】 Diabetes mellitus,type 2; Diabetic neuropathies; Insulin -like growth factor 1 糖尿病神经病变 (diabetic peripheral neuropathy,DPN) 是最常见的糖尿病慢性并发症，据报道， DPN 发生率为25% ~90%,是导致糖尿病足溃疡的重要原因，目前尚无有效的 治疗方法。胰岛素样生长因子1 (insulin like growth