肥胖对初诊2型糖尿病患者血清β抑制素2及胰岛素抵抗的影响.docVIP

· 1238 · · 论 著 · 肥胖对初诊2型糖尿病患者血清β抑制素2 及胰岛素抵抗的影响 潘佳秋，王萌，郭晓闻，于学静，杨玉芝，张超，杨玉红，谭丽艳 【摘要】 目的 探讨肥胖对新诊断2型糖尿病 (T2DM) 患者血清β抑制素2及胰岛素抵抗的影响。方法 选 取2012年6—12月在本院内分泌科就诊的新诊断 T2DM 肥胖患者30例 (T2DM 肥胖组， BMI≥28 kg/m2)、 新诊断 T2DM 非肥胖患者30例 (T2DM 非肥胖组， BMI24 kg/m2)、 体检健康者30例(对照组)。检测3组受检者空腹血清 β抑制素2水平及其他实验室检查指标，计算胰岛素抵抗指数 (HOMA-IR)、 胰岛β细胞功能指数 (HOMA- β) 和 胰岛素敏感性指数 (ISI)。 多组间均数比较采用方差分析，β抑制素2相关因素分析采用 Spearman 相关分析。结果 对照组、T2DM 非肥胖组、 T2DM 肥胖组血清β抑制素2水平依次降低〔(341.5±14.4)、(332.4±17.7)、(319.1 ±15.8)ng/L,P0.05]。BMI 与HOMA-IR 呈正相关，与ISI呈负相关 (P0.01);β 抑制素2与BMI、HOMA-IR 呈负相关，与ISI 呈正相关 (P0.01)。 结论 肥胖是影响T2DM患者血清β抑制素2水平及胰岛素抵抗的重要因素； 肥胖的T2DM 患者血清β抑制素2水平较体质量适中的T2DM 患者降低，且胰岛素抵抗进一步加剧。 【关键词】 糖尿病，2型；肥胖；β抑制素2;胰岛素抵抗 【中图分类号】 R587.1 【文献标识码】 A doi:10.3969/j.issn.1007-9572.2014.11.08 潘佳秋，王萌，郭晓闻，等.肥胖对初诊2型糖尿病患者血清β抑制素2及胰岛素抵抗的影响 [J]. 中国全科医 学，2014,17(11):1238-1240.[] I mpact of Obesity on Serum β- arrestin 2 and Insulin Resistance in Newly Diagnosed T2DM Patients PAN Jia -qiu, WANG Meng,GUO Xiao-wen, et al. Department of Endocrinology, the First Affiliated Hospital of Jiamusi University,Jiamusi 154002,China 【Abstract] Objective To explore the effect of obesity on serum β- arrestin 2 and insulin resistance(IR)in newly diagnosed type 2 diabetes(T2DM)patients. Methods In the Department of Endocrinology, the First Affiliated Hospital of Jiamusi University from June to December 2012,30 obese patients newly diagnosed as T2DM(obese group,BMI≥28 kg/m2), 30 non-obese patients newly diagnosed as T2DM(non-obese group,BMI24 kg/m2),30 healthy subjects(control group) were enrolled in this study. Fasting serum β- arrestin 2 level and other laboratory examination indicators were determined,insu- lin resistance index(HOMA-IR),pancreatic β- cell function index(HOMA-β), insulin sensitivity index(ISI) were cal- culated. Variance analysis was used to compare means, Spearman correlation analysis was used to analyze β-arrestin 2 related factors. Results The levels of β- arrestin 2 reduced in groups control, obese, non -obe