不同病程2型糖尿病患者血清C反应蛋白水平的比较.docVIP

·494 · · 论 著 · 不同病程2型糖尿病患者血清C 反应蛋白水平的比较 马广蕊，金秀平 【摘要】 目的 比较不同病程的2型糖尿病 (T2DM) 患者血清C 反应蛋白 (CRP) 水平，并探讨与血清 CRP 相关的因素。 方法 将98例T2DM 患者按病程分为3组：5年者为A 组，5年≤病程15年者为B 组，≥15年者为 C 组。用乳胶增强免疫速率散色比浊法定量检测3组患者血清高敏 C 反应蛋白 (hs-CRP) 水平，比较3组间的差异， 并分析血清hs-CRP 水平与各代谢指标的相关性。 结果 C 组患者hs-CRP 水平〔(3.64±0.81) mg/L〕较 A 、B 两 组〔(2.64±0.99) mg/L 与(3.13±0.56) mg/L〕 显著增高，差异有统计学意义 (P0.05)。 单因素直线相关分析 显示，血清hs-CRP 水平与糖尿病病程 (r=0.403,P=0.000)、 并发症数 (r=0.383,P=0.000)、 收缩压 (r= 0.232,P=0.021) 均呈正相关，与高密度脂蛋白呈负相关 (r=-0.300,P=0.003)。 多因素直线相关分析亦得出上 述结果。 结论 T2DM 患者血清 hs-CRP 水平随病程的延长、并发症数目的增多、收缩压的升高而升高，与糖尿病大 血管及微血管并发症的发生、发展关系密切。 【关键词】 C反应蛋白；糖尿病，2型；病程 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2011)02-0494-03 Changes of C- reactive Protein Levels in Type 2 Diabetic Patients with Different Course of Desease MA Guang - rui, JIN Xiu-ping. Department of Endocrinology, Third Hospital of Tangshan City, Tangshan 063100,China 【Abstract】 Objective To study the changes of C - reactive protein(CRP)in type 2 diabetes patients with different courses, and to discuss related factors. Methods 98 patients with Y2DM were divided into three groups according to the course of disease. Group A, course 5 years; Group B, course during 5 - 15 years and group C,course≥15 years. The High - sen- sitivity C-reactive protein(hs - CRP)levels of the three groups were detected by latex boost the immune rate of bulk - color Turbidimetry. Compare the differences of hs - CRP in the three groups and analyze the relevance between hs - CRP levels and the course of the disease, complications and metabolic indicators. Results Compared with Group A and B, CRP levels in Group C were significantly higher [(3.64±0.81)vs.(2.64±0.99)mg/L,P0.05;(3.64±0.81)vs.(3. 13±0.56)mg/L, P0.05]. Single factor line analysis showed that the serum hs -CRP levels were positively correlated with diabetes duration (r =0.403,P=0.000),the number of complications(r=0.383,P=0.0