药理学英文版教学课件：Chapter 3 Pharmacokinetics.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * 24 * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Note: Important Pharmacokinetic parameters Volume of distribution Vd = DOSE / Co Plasma clearance CL= Kel .V plasma half-life (t1/2) t1/2 = 0.693 / Kel Bioavailability F= (AUC)x / (AUC)iv §3 Time Course of Drug Concentration  Single administration 0 20 40 60 80 100 120 0 2 4 6 8 10 Time (min) Plasma aspirin concentration (mg/L) Cmax Tmax i.v p.o Multiple dosing，p22 Cons