Omega-3 PUFA在心力衰竭中的作用.pdf

Omega-3PUFA在心力衰竭中的作用

0mega-3PUFA水平与心力衰竭风险的关系

与心力衰竭的发生风险呈显著负相关。研究共纳入13项研究，主要通过检测

膳食摄入量，或血液循环中的含量来评估长链脂肪酸水平的高低，研究的主要

结果如下：

衰风险越低(最高与最低五分位数相比：HR=0.84,95

I=0.75-

0.94,p=0.02)(图1);

RiskRdioRiskRdio

loglRiskRatinLSEWeinitIV,Random.95Ye

SndyerSibnoipN.Ramloms99:CL

HiyhestOuhdleevsLowOulatiles

Mozafiaran2005-04620.20426.1%0.6310.42,0.942005

-0.54470.24054.6%

Yamagithi2006Accstuty0.5810.36,0.932008

Levtan2010-0.28770.1276123%0.7510.58.0.982010

Bein2011-0.06820.076821.4%0.9310.80,1.092011

WIk2012-0.06190.115214.1%0.9410.75,1.1@2012

Dehstre2009-0.11650.12712.3%0.8910.60,1.142019

Akesson2019-0.27440.095717.4%0.76|0.62,0.92]2019

Levtan20091.00j0.77,1.292019

00.130711.9%

Subtoti(99?100.0%

0.84[075,0.94j

Heteroganety.Tau2=0.0t,CN2=10.94,0f=7P=0.14,P=38%

TestforoveraleffectZ=3.16P=0.002)

PerSDimcemnt

Mozadfanian2005-0.16490.07375.9%

0.8510.73,0.982005

-0.19480.0874.4%0.8210.69,0.982008

Yamagisni2008-ACCstuty

Levtan2010-0.10310.046812.0%0.90[0.82,0.910

0.9710.92,1.032011

Bein2011-0.02630.027421.9%

Wik2012-0.02220.041314.1%0.9810.90,1082012

Akesson2019-0.09810.034117.7%0.9110.85,0.972019

004190.046212.2%

Dikstra20090.96j0.BE,1.092019

00.047611.7%

Levtan20091.0010.91,1.102019

Suhtetit99CD0.94[090,0.981

100.0%

Heterogemety:Tau2=0.00,CH2=10.58,df=7P=0.10;P=3%

TestforweralefetZ=3.19P=0.00