HDAC-IN-70-DataSheet-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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HDAC-IN-70

Cat.No.:HY-162377

分⼦式:C₁₈H₁₄N₄O₃

分⼦量:334.33

作⽤靶点:HDAC;Apoptosis;Necroptosis

作⽤通路:CellCycle/DNADamage;Epigenetics;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性HDAC-IN-70(compound4c)为HDAC6抑制剂，对HDAC6、HDAC1、HDAC2和HDAC4的IC50值分别为

64.13nM、166nM、618nM和253nM。HDAC-IN-70诱导细胞周期阻滞，凋亡(apoptosis)和坏死。HDAC-

IN-70可⽤于⽩⾎病的研究。

IC50TargetHDAC6HDAC1HDAC2HDAC4

64.13nM(IC50)166nM(IC50)618nM(IC50)253nM(IC50)

体外研究HDAC-IN-70(compound4c)(0-120μM)showscytotoxicactivityagainstCCRF-CEMandMOLT-4cellswith

theIC50valuesof1.82,6.73μM[1].

HDAC-IN-70(1.82μM,24h)arrestscellcycleatG2-MphaseinCCRF-CEMcells[1].

HDAC-IN-70(1.82μM,24h)increasesthepercentageoftotalapoptosisandnecroticinCCRF-CEMcells

[1].

HDAC-IN-70(1.82μM,24h)increasesthelevelofacetylatedhistonesH3,H4inCCRF-CEMleukemiacells

[1].

CellCycleAnalysis