乳腺癌人表皮生长因子受体2表达对乳腺癌临床诊断与预后评估的意义.docVIP

乳腺癌人表皮生长因子受体2表达对乳腺癌临床诊断与预后评估的意义

[摘要]目的：分析X线影像组学评估乳腺癌人表皮生长因子受体2（humanepithelialgrowthfactorreceptor-2，HER-2）表达对乳腺癌的诊断价值。方法：将医院2017年5月—2019年5月收治的经免疫组化及手术病理证实的浸润性乳腺癌患者138例作为研究对象，术前行X线影像组学及彩色多普勒超声检查，术后行病理免疫组化检测HER-2表达水平。回顾性分析X线的临床特征及其与乳腺癌HER-2阳性表达之间的相关性，以探讨X线影像组学对乳腺癌的诊断价值。结果：纳入患者中，HER-2表达阳性者52例（37.68%），HER-2表达阴性者86例（62.32%）。HER-2阳性组患者单纯肿块、单纯钙化、肿块伴钙化征象与HER-2阴性组比较差异有统计学意义（x2＝6.105、9.110、4.567，P＝0.013、0.003、0.033）；HER-2阳性组肿块形态、肿块边界、恶性钙化分布、钙化形态与HER-2阴性组比较差异显著（P＜0.05）。X线影像组学预测HER-2表达的ROC曲线下面积为0.74±0.18，评估乳腺癌HER-2表达的敏感性为74.6%。结论：乳腺癌的X线影像组学特征与HER-2表达存在相关性，乳腺癌HER-2阳性型因其生物学特征表现出独特的X线影像特征，本研究可为乳腺癌的临床诊断与预后评估提供参考依据。

[关键词]X线影像组学；乳腺癌；HER-2；临床特征；诊断价值

Significanceofhumanepidermalgrowthfactorreceptor2expressioninbreastcanceronclinicaldiagnosisandprognosisofbreastcancer

[Abstract]Objective:ToanalyzethediagnosticvalueofbreastcancerHER-2expressioninbreastcancerbyX-rayimaging.Method:138casesofinvasivebreastcancerpatientsconfirmedbyimmunohistochemistryandpathologyconfirmedbythehospitalfromMay2017toMay2019werestudied.X-rayimagingandcolorDopplerultrasonographywereperformedbeforeoperation.PathologicalimmunohistochemistrywasusedtodetectHER-2expressionlevels.TherelationshipbetweentheclinicalfeaturesofX-rayandthepositiveexpressionofHER-2inbreastcancerwasretrospectivelyanalyzedtoinvestigatethediagnosticvalueofX-rayimaging.Result:Amongthepatients,52(37.68%)werepositiveforHER-2and86(62.32%)werenegativeforHER-2.ThereweresignificantdifferencesbetweentheHER-2positivegroupinthesimplemass,simplecalcification,masswithcalcificationandHER-2negativegroup（x2＝6.105、9.110、4.567,P＝0.013、0.003、0.033）;Themorphology,massboundary,malignantcalcificationdistributionandcalcificationmorphologyofHER-2positivegroupweresignificantlydifferentfromthoseofHER-2negativegroup(P0.05).TheareaundertheROCcurveforpredictingHER-2expressionbyX-