sTWEAK在子痫前期患者血清中的表达及其意义-.docVIP

sTWEAK在子痫前期患者血清中的表达及其意义

【摘要】目的:检测子痫前期患者的外周血血清中sTWEAK的表达水平，并分析其临床意义。方法：选取2017年5月至2019年3月在上海交通大学附属新华医院崇明分院产检及入院分娩的轻度子痫前期、重度子痫前期及正常孕妇共90例，采用酶联免疫吸附试验（ELISA）方法检测外周血sTWEAK的表达水平。结果：与正常孕妇组相比，重度子痫前期组及轻度子痫前期组的体重指数明显升高（P＜0.01），重度子痫前期组的糖化血红蛋白明显升高（P＜0.01）。与重度子痫前期组相比，轻度子痫前期组的糖化血红蛋白明显降低（P＜0.01）。重度子痫前期组、轻度子痫前期组及正常孕妇组的sTWEAK表达水平三组比较，差异均有统计学意义（P＜0.01）。与血糖正常组相比，血糖异常组孕妇sTWEAK的表达水平明显降低（P＜0.01）。与BMI＜24组孕妇相比，BMI≥24组的孕妇sTWEAK的表达水平明显降低（P＜0.01）。所有孕妇sTWEAK的表达水平与体重指数呈负相关性（rs=-0.339，P=0.001），与糖化血红蛋白呈负相关性（rs=-0.251，P=0.017）。结论：孕晚期sTWEAK的表达与子痫前期的发生及进展相关，其表达水平可能对预测子痫前期患者是否存在糖尿病或超重等代谢异常具有一定的作用。

【关键词】子痫前期；sTWEAK；酶联免疫吸附测定

SerumsTWEAKExpressionandItsClinicalSignificanceinpreeclampsiaPatients

[Abstract]Objective:Toexploretheexpressionlevelandclinicalimplicationsofserumsolubletumornecrosisfactor—likeweakinducerofapoptosis（sTWEAK）inpreeclampsiapatients.Methods:90patientsofmildpreeclampsia,severepreeclampsiaandnormalpregnantwomenwereselectedfromXinhuaHospitalChongmingBranch，SchoolofMedicine,ShanghaiJiaoTongUniversity.ThesepatientswereadmittedtothehospitalduringtheperiodfromMay2017toMarch2019.ThelevelsofserumsTWEAKweredetectedbyEnzyme-linkedimmunosorbentassay(ELISA).Results:Comparedtothenormalpregnantgroup,thebody?mass?index(BMI)oftheseverepreeclampsiagroupandthemildpreeclampsiagroupweresignificantlyincreased(P0.01),andtheglycosylated?hemoglobin(HbA1c)intheseverepreeclampsiagroupweresignificantlyincreased(P0.01).Comparedtotheseverepreeclampsiagroup,theHbA1cinthemildpreeclampsiagroupweresignificantlyreduced(P0.01).sTWEAKexpressionlevelsofseverepreeclampsiagroup,mildpreeclampsiagroupandnormalpregnantwomengroupshowedstatisticallysignificantdifferences(P0.01).Comparedtothenormalgroup,theexpressionlevelsofsTWEAKofpregnantwomeninthegroupwithabnormalbloodglucoseweresignificantlydecreased(P0.01).Comparedtotheg