新生儿出生缺陷相关因素分析及预防措施 .pdf

h出生缺圈目关因跄顽醐昔施

【摘要】目的：分析新生儿出生缺陷相关因素，并对预防措施进行探讨。法：选取2020年1月一2022年12

月期间在全区出生的发生出生缺陷的628例患儿作为观察组，同时选取同期出生的628例健康新生儿作为对照组。收集

两组的基本资料，分析出生缺陷的影响因素。结果：观察组产妇年龄35岁、孕期患病、孕期服用药物及异常生育史比

例高于对照组，孕前保健、孕早期服用叶酸及规律服用叶酸比例低于对照组(Pv0.05)；Logistic回归分析显示，年龄35

岁、未接受孕前保健、孕早期未服用叶酸、叶酸应用不规律、孕期患病、孕期服用药物及有异常生育史是发生出生缺陷

的危险因素(Pv0.05)。结论：未接受孕前保健、高龄产妇、孕早期未使用或未规律使用叶酸、患病、用药及异常生育

史均是出生缺陷的危险因素，应针对以上因素采取针对性的预防措施，做好优生优育工作。

【关键词】新生儿；出生缺陷；影响因素；预防

Analysisoffactorsrelatedtobirthdefectsinnebornsandexplorationofpreventivemeasures

LIUYaqian

ZhangdianDistrictMaternalandChildHealthHospital,ZiboCity,Shandong,Zibo,Shandong255000,

China

［Abstract］Objective：Toanalyzethefactorsrelatedtobirthdefectsinnebornsandexplorepreventive

measures.Methods：628childrenithbirthdefectsbornintheentireregionbeteenJanuary2020andDecember

2022ereselectedastheobservationgroup,hile628healthynebornsborninthesameperiodereselectedas

thecontrolgroup.Collectingbaselinedatafromtogroupsandanalyzingtheinfluencingfactorsofbirth

defects.Results：Theproportionofparturientsagedover35yearsold,ithpregnancyrelatedillnesses,medication

useduringpregnancy,andabnormalfertilityhistoryintheobservationgroupashigherthanthatinthecontrolgroup,

hiletheproportionofprepregnancyhealthcare,earlypregnancyfolicaciduse,andregularfolicaciduseasloer

thanthatinthecontrolgroup(P0.05)；Logisticregressionanalysisshoedthatage35yearsold,failuretoreceive

prepregnancycare,failuretotakefolicacidinearlypregnancy,irregularuseoffolicacid,pregnancyrelatedillnesses,

medicationuseduringpregnancy,andahistoryofabnormalfertilityereriskfactorsforbirthdefects

(P0.05).Conclusion：Failuretoreceiveprepregnancycare,advancedmaternalage,failuretouseorirreg