放射治疗与免疫调节：抗VEGF VEGFR2轴增强放疗抵抗性研究.pdfVIP

Anti-VEGF/VEGFR2axisenhancesradio-

resistanceviaregulatoryT-celldepletion

汇：

其他成员：、、

2016-11-3

Contents

1.RadiationenhancesregulatoryTcellrepresentation

2.Tregcontributetotheresistanceoftumortoradiation

3.VEGFA-VEGFRpathwayblockadecaninhibitregulatory

T-cellproliferation

4.Raisingmyhypothesis

1.RadiationenhancesregulatoryTcell

representation

ImmuneMechanismsTriggeredbyTumorIrradiation

HerreraFG,etal.CACancerJClin.2016Aug29.

RadiotherapyReprogramstheTumorMicroenvironment

HerreraFG,etal.CACancerJClin.2016Aug29.

ReportedClinicalCasesofAbscopalEffectsof

RadiotherapyinCombinationWithImmunotherapy

HerreraFG,etal.CACancerJClin.2016Aug29.

Tregcellsincreasetemporarilyafterlocalirradiation.

KachikwuEL,etal.IntJRadiatOncolBiolPhys.2011Nov15;81(4):1128-35.

Theradiation-inducedincreaseinTregcellsisdose

dependent.

KachikwuEL,etal.IntJRadiatOncolBiolPhys.2011Nov15;81(4):1128-35.

Lowradiationdosestothewholebodyreducedspleen

size,weight,andcellnumberswhileincreasingthe

proportionofsplenicTregulatory(Treg)cells.

KachikwuEL,etal.IntJRadiatOncolBiolPhys.2011Nov15;81(4):1128-35.

+high

DifferentresponsesofCD4CD25Tcellsand

+-

CD4CD25Tcellstoirradiationinvitro.

QuY,etal.RadiatRes.2010;173:148-157.

FlowcytometryanalysisofBcl-2expressionin

+high+-

CD4CD25TcellsandCD4CD25Tcells.

QuY,e