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BRL34778

Cat.No.:HY-106820

CASNo.:86580-77-0

分⼦式:C₂₃H₂₇ClFN₃O₂

分⼦量:431.93

作⽤靶点:DopamineReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BRL34778是⼀种强效、选择性且具有⼝服活性的多巴胺D2受体(dopamineD2receptor)拮抗剂，其Ki值

为2.14nM。BRL34778具有抗精神病活性，且锥体外系反应和镇静作⽤较弱。BRL34778可⽤于神经系统疾

病的研究，如精神分裂症[1]。

IC50TargetD2Receptor

2.14nM(Ki)

REFERENCES

[1].BrownF,etal.TheselectivedopamineantagonistpropertiesofBRL34778:anovelsubstitutedbenzamide.Psychopharmacology

(Berl).1988;94(3):350-8.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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