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DPO-1(Standard)

Cat.No.:HY-100712R

CASNo.:43077-30-1

分⼦式:C₂₂H₂₉OP

分⼦量:340.44

作⽤靶点:PotassiumChannel;ReferenceStandards;CalciumChannel;

NOD-likeReceptor(NLR);InterleukinRelated

作⽤通路:MembraneTransporter/IonChannel;Others;Neuronal

Signaling;Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DPO-1(Standard)是DPO-1(HY-100712)的分析标准品。本产品⽤于研究及分析应⽤。DPO-1是⼀种强效的

Kv1.5和Kv1.3(EC50=3.1μM)通道抑制剂。DPO-1降低Kv1.3电流密度，减弱Ca2+耗竭的Jurkat细胞中

Ca2+流⼊，并抑制活化Jurkat细胞中IL-

REFERENCES

[1].TsvetkovD,etal.TheRoleofDPO-1andXE991-SensitivePotassiumChannelsinPerivascularAdiposeTissue-MediatedRegulationof

VascularTone.FrontPhysiol.2016Aug4;7:335.

[2].ZhaoN,etal.PotentsuppressionofKv1.3potassiumchannelandIL-2secretionbydiphenylphosphineoxide-1inhumanTcells.PLoS

One.2013May22;8(5):e64629.

[3].LiP,etal.Kv1.5channelmediatesmonosodiumurate