Intoplicine-dimesylate-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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Intoplicinedimesylate(Standard)

Cat.No.:HY-101647AR

CASNo.:133711-99-6

分⼦式:C₂₃H₃₂N₄O₇S₂

分⼦量:540.65

作⽤靶点:Topoisomerase;ReferenceStandards

作⽤通路:CellCycle/DNADamage;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Intoplicine(dimesylate)(Standard)是Intoplicine(dimesylate)(HY-101647A)的分析标准品。本产品⽤于研

究及分析应⽤。Intoplicine(RP60475)dimesylate，⼀种7H苯并[e]吡啶并[4,3-b]吲哚系列的抗肿瘤衍⽣物

，是⼀种DNA拓扑异构酶I和II抑制剂。Intoplicinedimesylate与DNA(KA=2x

REFERENCES

[1].RiouJF,etal.Intoplicine(RP60475)anditsderivatives,anewclassofantitumoragentsinhibitingbothtopoisomeraseIandIIactivities.

CancerRes.1993;53(24):5987-5993.

[2].EckardtJR,etal.Activityofintoplicine(RP60475),anewDNAtopoisomeraseIandIIinhibitor,againsthumantumorcolony-forming

unitsinvitro.JNatlCancerInst.1994;86(1):30-33.

[3].BisseryMC,etal.Antitumoractivityofintoplicine(RP60475,NSC645008),anewbenzo-pyrido-indole:evaluationagainstsolidtumors

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