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Melafolone

Cat.No.:HY-165394

CASNo.:129724-42-1

分⼦式:C₂₂H₂₄O₇

分⼦量:400.42

作⽤靶点:COX;EGFR;PD-1/PD-L1;PI3K;Akt

作⽤通路:Immunology/Inflammation;JAK/STATSignaling;Protein

TyrosineKinase/RTK;PI3K/Akt/mTOR

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Melafolone是⼀种有效的COX-2/EGFR双重抑制剂，其对COX-2和EGFR的IC50值分别为13.2μM和17.4

μM。Melafolone在Lewis肺癌(LLC)和CMT167模型中，通过PI3K/Akt通路促进⾎管正常化和下调PD-L1

表达，从⽽增强抗PD-1作⽤效果。Melafolone可⽤于肺癌相关研究[1]。

IC50TargetCOX-2EGFR

13.2μM(IC50)17.4μM(IC50)

REFERENCES

[1].TangH,etal.InhibitionofCOX-2andEGFRbyMelafoloneImprovesAnti-PD-1TherapythroughVascularNormalizationandPD-L1

DownregulationinLungCancer.JPharmacolExpTher.2019Mar;368(3):401-413.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.