MDL-27531-生命科学试剂-MCE.pdfVIP

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MDL-27531

Cat.No.:HY-W975902

CASNo.:116850-44-3

分⼦式:C₁₀H₁₁N₃O₂S

分⼦量:237.28

作⽤靶点:GlycineReceptor(GlyR)

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MDL-27531在功能上类似于⽢氨酸激动剂。MDL-27531选择性地减少后肢收缩。MDL-27531选择性地逆转

⼠的宁诱导的⼩⿏癫痫发作。MDL-27531以55mg/kg的ED50值抑制戊四唑诱导的癫痫发作。MDL-27531

促进苯⼆氮卓类拮抗剂Ro15-1788与⼩⿏⼤脑⽪层的结合，但不改变GABA⽔平。MDL-27531可⽤于反射控

制功能障碍的研究[1][2]。

REFERENCES

[1].Kehne,J.H.,etal.,(1992).MDL27,531reducesspontaneoushindlimbcontractionsinratswithchronictransectionsofthespinalcord.

Neuroscienceletters,147(1),101–105.

[2].Kehne,J.H.,etal.,(1992).MDL27,531selectivelyreversesstrychnine-inducedseizuresinmice.Britishjournalofpharmacology,

106(4),910–916.

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